The Database of Biomarkers: Depression: S100B

The potential biomarkers of depression:


Associated diseases:

Burnout syndrome

Population group:

Emergency medicine residents


Burnout syndrome is a common issue among emergency healthcare workers. It may be related to fatigue and job separations. S100 calcium-binding protein B (S100B) is a protein found in the cytoplasm and nucleus of various cells. It is important in the regulation of many essential cellular activities including cell cycle progression and differentiation.

A recent study analyzed the role of the glial marker S100B among 48 emergency medicine residents with the problems of burnout syndrome and depression (Gulen et al. 2016). In the study, the S100B levels were tested before and after the night shifts. The Maslach Burnout Inventory (MBI) and the Beck Depression Inventory (BDI) were used to assess the burnout syndrome and depression. The study found that most of the samples had severe depression (Gulen et al. 2016).

The study suggests that the S100B levels were associated with depression and emotional exhaustion in burnout syndrome (Gulen et al. 2016). In addition, significant differences of the median S100B levels were observed between severe depression and moderate depression, as well as before and after night shifts.

Such analysis indicates that the S100B levels may be a potential biomarker that can be used to measure the risks for the development of depression and burnout syndrome under stress conditions. More studies are still needed to validate its applications.


Gulen B, Serinken M, Eken C, Karcıoglu Ö, Kucukdagli OT, Kilic E, Akpinar G, Nogay S, Kuh M. Serum S100B as a Surrogate Biomarker in the Diagnoses of Burnout and Depression in Emergency Medicine Residents. Acad Emerg Med. 2016 Jul;23(7):786-9. doi: 10.1111/acem.12973.

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