The Database of Biomarkers: Depression: Adiponectin

The potential biomarkers of depression:


Associated diseases:

Chronic hepatitis C

Population group:

Patients with hepatitis C virus (HCV) infections


Major depression (MD) is often observed among patients with hepatitis C virus (HCV) infections. These patients treated with interferon (IFN)-α may develop a depressive syndrome related to inflammatory profiles. A recent study examined 50 HCV-infected patients with psychiatric assessments (Fábregas et al. 2016).

The study analyzed the variables including the plasma levels of brain-derived neurotrophic factor (BDNF), tumor necrosis factor (TNF) and the soluble type 1 and type 2 receptors (sTNFR1 and sTNFR2) (Fábregas et al. 2016). The study also tested the levels of adipokines including adiponectin, leptin, as well as resistin. Encoded by the ADIPOQ gene, adiponectin is associated with the glucose homeostasis and the metabolism of fatty acids.

The study found that older patients and those who were not married had increased levels of body mass index (BMI) and liver inflammation with decreased levels of baseline adiponectin (Fábregas et al. 2016). In addition, the utilizations of IFN were related to the symptoms of depression. The study indicated that adiponectin could be a biomarker for major depression among patients with HCV infections.


Fábregas BC, Vieira ÉL, Moura AS, Carmo RA, Ávila RE, Abreu MN, Prossin AR, Teixeira AL. A Follow-Up Study of 50 Chronic Hepatitis C Patients: Adiponectin as a Resilience Biomarker for Major Depression. Neuroimmunomodulation. 2016;23(2):88-97. doi: 10.1159/000444531.

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