Tag Archives: signaling pathways

Systems biology approaches for the pharmacokinetic/pharmacodynamic (PK/PD) modeling in drug discovery and development

Systems biology-enabled computational modeling can be useful in almost every step of drug discovery and development, including drug target identification and clinical outcome analysis. Various modeling strategies can be used at different stages. For example, during the basic scientific research … Continue reading

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Review of Systems Biology Approaches: Detecting Signaling Pathways in Neurons

Temporal dynamics and spatial features are important factors in cell responses including synaptic plasticity. The complex network and interactions among neuronal signaling pathways result in emergent dynamical behaviors associated with synaptic plasticity. Signaling pathways can be activated by transmembrane receptors … Continue reading

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