Tag Archives: mutations

Psychiatric Symptoms and the Gene SGCE (Sarcoglycan Epsilon)

The SGCE gene has other symbols as “ESG” and “DYT11”. It is located at 7q21.3. As a member of the sarcoglycan family, it is a component of the dystrophin-glycoprotein complex (DGC). It provides the connections between the actin cytoskeleton and … Continue reading

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Epilepsy and the Gene KCNT1 (Potassium Sodium-Activated Channel Subfamily T member 1)

The KCNT1 gene has other symbols as “ENFL5”, “SLACK”, “EIEE14”, “KCa4.1”, “Slo2.2”, and “bA100C15.2”. It is located at 9q34.3. Encoding a sodium-activated potassium channel, this gene is highly expressed in the brain (Nagase et al. 2000). It has been related … Continue reading

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The Database of Biomarkers: Proteomic and Pathway Biomarkers – Cancers

Associated diseases/conditions: Non-small cell lung cancer (NSCLC)   Potential Biomarkers: Insulin-like growth factor (IGF) pathway   Detections: Protein expressions, serum levels   Potential Applications: Predictive biomarkers (tumor progression and patient outcomes)   References: Shersher DD, Vercillo MS, Fhied C, Basu … Continue reading

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Individualized systems medicine (ISM): applications in the treatment of acute myeloid leukemia (AML)

Approaches in individualized systems medicine (ISM) or personalized systems medicine would be useful for achieving optimal therapies, especially in cancer treatment. Strategies in ISM have been suggested by Pemovska et al., by focusing on the establishment of molecular profiling (Pemovska … Continue reading

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