Tag Archives: genes

Translational Medicine and Drug Discovery

Recent development in translational medicine provides a connection between basic scientific studies and clinical practice. Such an initiative may support the patient-centered objectives in both research and clinical environments. It may also improve the drug discovery procedure by allowing for … Continue reading

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Systems Biology Technologies and Cancer Immunotherapy

Decades of scientific studies have demonstrated the essential role of the immune system in cancer pathology and clinical treatment. The immune system may regulate the growth of tumors via the complex interactions among molecules, genes, cells, and organs. The elucidation … Continue reading

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Epilepsy and the Gene KCNT1 (Potassium Sodium-Activated Channel Subfamily T member 1)

The KCNT1 gene has other symbols as “ENFL5”, “SLACK”, “EIEE14”, “KCa4.1”, “Slo2.2”, and “bA100C15.2”. It is located at 9q34.3. Encoding a sodium-activated potassium channel, this gene is highly expressed in the brain (Nagase et al. 2000). It has been related … Continue reading

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Psychiatric Diseases and the Gene DISC1 (Disrupted in Schizophrenia 1)

The DISC1 gene has other symbols as “SCZD9” and “C1orf136”. It is located at 1q42.2. It is involved in the regulation of the AKT-mTOR signaling pathway and associated with embryonic and adult neurogenesis (Kim et al. 2009). DISC1 has been … Continue reading

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Stress, Depression, Inflammation, and Personalized Medicine

Stress, Depression, Inflammation, and Personalized Medicine Psychological stress has been associated with higher levels of inflammation and the risks of many physical disorders including heart diseases. For example, chronic stress responses may cause a variety of skin disorders including allergic … Continue reading

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The Circadian Clock, Genes, and Systems Biology

The circadian clock is essential in many organisms. The circadian timing system enables the physiological and behavioral adaptation to the external geophysical changes through the regulation of the temporal cellular processes (Lehmann et al., 2015). In mammals, the master pacemaker … Continue reading

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Systems Biology and Subnetworks in Breast Cancer

As a complex disease with heterogeneous factors involved, breast cancer have various subtypes with distinct therapeutic response patterns and outcomes (Yersal and Barutca, 2014). Conventional classification systems of breast cancer have limitations in describing such features. In order to achieve … Continue reading

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The Database of Biological Rhythms (DBBR)

The Database of Biological Rhythms (DBBR) The Chronobiology Portal: Chronobiology, Chronotherapy, Circadian Rhythms, and More Journals about Biological Rhythms and Chronobiology   Biological Rhythm Research Chronobiology International Journal of Biological Rhythms Journal of Chronotherapy and Drug Delivery Journal of Circadian … Continue reading

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Genetic Factors, Quantitative Trait Loci, and Human Personality

Both genetic and environmental factors can influence human personality. Genetic factors may affect about half of trait disparity. Their effects are highly complex with gene-gene and gene-environment interactions. To link specific genes with quantitative traits, the analysis of quantitative trait … Continue reading

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Psychoneuroimmunology and Addictive Disorders: Potential New Therapies

Addictive disorders are often chronic relapsing problems with high health, social, and economic costs. Problems such as alcohol use disorders affect about 76.4 million people globally, and drug use disorders affect about 15.3 million people (Loftis and Huckans, 2013). As … Continue reading

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Systems medicine, P4 medicine, and an integrative “Human Model”

Conventional practice in Western medicine focuses on doctors’ “reactive” interventions in response to the occurrence of diseases. With the advancement of genomics, proteomics, and various high efficient “omics” technologies, the multidimensional networks of the human body can be investigated for … Continue reading

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