Tag Archives: gene expression

Resilience, Adversity, Gene Expression, and Wellbeing

Chronic social adversity may lead to a “conserved transcriptional response to adversity (CTRA)” with higher levels of pro-inflammatory genes and lower levels of antiviral- and antibody-related genes. Certain psychological resilience factors have been found to alleviate CTRA (Cole et al., … Continue reading

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Biomarkers for Inflammatory Breast Cancer

Inflammatory breast cancer (IBC) is an aggressive type of breast cancers (BC). Currently only a few specific genetic biomarkers or signatures have been identified for the disease. However, these genetic signatures are not very representative (Remo et al. 2015). More … Continue reading

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Systems Biology and Biomarkers in Neuropsychiatry

Neuropsychiatric (NP) disorders such as autism spectrum disorders (ASD) are the leading causes of disability around the world. However, because of their complexity, the etiology and pathophysiology of NP diseases are still mostly unknown. Such complexity may be caused by … Continue reading

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Glucocorticoids, Shift Work, and the Central and Peripheral Clocks

The circadian system can be influenced by both the environment and human activities. For example, shift work can cause a de-synchronization between the circadian timing system in the human body and the external environment (Cuesta et al, 2014). Such disruption … Continue reading

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Grief, Bereavement and Immune Dysfunction: The Role of Psychoneuroimmunology

Mental and emotional reactions such as grief and bereavement have been linked to cortisol responses and neuroendocrine activations, as well as alterations in electroencephalography (EEG) records and sleep disorders (Buckley et al., 2012). More importantly, bereavement has been suggested to … Continue reading

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The integration of various “omics” technologies in systems biology for better diagnosis and treatment

With the advancements in the “omics” technologies and the information technology, systems biology has become an important approach for biomarker discovery. These technologies allow faster and cheaper analyses of gene expression, protein interactions, signaling pathways, and metabolic mechanisms. In this … Continue reading

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Neuroinformatics Software and Ontology Tools

Neuroinformatics Software and Ontology Tools     Category Source Name Purposes/Features/Methods Contents Applications URL References Neuroimaging Informatics Tools BrainVisa (BV) For high resolution MR images To quantify global and regional variances About cortical anatomy A plug-in application for structural analysis … Continue reading

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Neuroinformatics: An Introduction

Neuroinformatics: An Introduction The challenges in neuroinformatics   Challenges in making neuroinformatics databases and tools (Morse, 2008) The variety in spatial scales Various data types Traditional bioinformatics concentrates on Genomic and proteomic data Sequences (DNA, RNA, and protein molecules) Development … Continue reading

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