Tag Archives: Alzheimer’s disease

Alzheimer’s Disease and the Gene APOE (Apolipoprotein E)

The APOE gene has other symbols as “AD2”, “LPG”, “APO-E”, and “LDLCQ5”. It is located at 19q13.2. The APOE gene has important roles in cardiovascular diseases including myocardial infarction, ischemic stroke, and coronary heart disease (Kathiresan et al. 2008). The … Continue reading

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Systems Biology, Immunity, Biomarkers, and Aging

Many chronic diseases are age-associated, including Alzheimer’s disease, cardiovascular disease, type 2 diabetes, and cancer. The elevating incidence of these disorders asks for the better understanding of the associations between the aging process and various diseases. With the increasing life … Continue reading

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Stress, Chronic Diseases, and Psychoneuroimmunology

Stress, Chronic Diseases, and Psychoneuroimmunology Although many chronic diseases such as cancer are apparently physical, they can lead to psychological distress. Chronic psychosocial stress may in turn affect the physical health negatively. Studies in psychoneuroimmunology (PNI) have shown that the … Continue reading

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Systems Biology, miRNAs, and Alzheimer’s Disease

Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial involving genomics, metabolomics, epigenomics, transcriptomics, interactomics, as well as environmental components. Systemic understanding of these complex diseases may start with the alterations in the cellular networks. Investigation in integrative systems biology … Continue reading

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The dynamic brain networks, MRI, and neuroimaging biomarkers

Processes in the cerebral cortex have the nonlinear and dynamic features. Accurate temporal coordination is necessary for the establishment of functional networks and assemblies. The brain is a complex and self-organized system with serial operations involved in highly interconnected networks. … Continue reading

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Psychopathology: A Summary of Types, Disorders, and Concepts

Psychopathology: A Summary of Types, Disorders, and Concepts   Concepts/Theories/Sources Categories Categories Components/Disorders Problems Examples/Details Types/Examples Mental disorder features (Holmes) Distress Psychological discomfort         Disability Unable to do daily activities         Deviance Abnormal mood, … Continue reading

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