Stress and Inflammatory Biomarkers in Psychiatric Disorders among Children and Adolescents

Inflammation, immune dysfunctions, and abnormal cytokine levels have been closely related to psychiatric disorders among adult patients in recent studies in psychoneuroimmunology (PNI). How about the associations between cytokine concentrations and psychosocial stress in children and adolescents (C&A)?

A recent study analyzed the profiles of cytokines in association with psychosocial stressors among 77 patients between 8 and 17 years old (Gariup et al., 2015). The patients had acute psychiatric conditions such as anxiety, and obsessive-compulsive disorders.

The study found elevated concentrations of interleukin (IL)-1β, IL6, IL8, IFN-γ-induced protein-10 (IP-10), monocyte chemoattractant protein (MCP)-1, and monocytes among the patient population (Gariup et al., 2015). Elevated level of stress was also observed in the group. The stress level was correlated with the inflammatory markers including IL-1β, IL-8, and MCP-1 among children.

Furthermore, the levels of IL8, IP10, and monocyte absolute count were categorized as the independent predictors (Gariup et al., 2015). These findings are meaningful for expanding the PNI models to children and adolescents.


Gariup M, Gonzalez A, Lázaro L, Torres F, Serra-Pagès C, Morer A. IL-8 and the innate immunity as biomarkers in acute child and adolescent psychopathology. Psychoneuroendocrinology. 2015 Dec;62:233-42. doi: 10.1016/j.psyneuen.2015.08.017.

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