Neuroinformatics Databases about the Brain-Related Diseases

Neuroinformatics Databases about the Brain-Related Diseases


Source Name






Autism National Database for Autism Research (NDAR) A secure database for data sharing, data harmonization, and collaboration in autism spectrum disorder researchers Data from more than 25,000 research participants Available to investigators via the NDAR portal Hall et al., 2012
Traumatic brain injury





BrainIT To analyze the application of hyperventilation and the compliance to Brain Trauma Foundation-Guidelines (BTF-G) after traumatic brain injury (TBI) Patients: 151 patients with trauma and recorded arterial blood-gas (ABG) analysis Analyzed ABGs

Ventilation episodes (VE)

Patients without increased intracranial pressure (ICP) showed higher P(a)CO(2)

Intensified forced hyperventilation without the elevated ICP was shown in VE

Early prophylactic hyperventilation was applied in VE Neumann et al., 2008
The Traumatic Brain Injury Model Systems National Data and Statistical Center (TBINDSC) To study the traumatic brain injury Secondary studies of the data sets

Measurements of demographic features, functional conditions, and hospital stay time

Patients’ data in the TBIMS-NDB

The significant variance in distribution was age

The TBIMS-NDB cohort did not have lots of patients older than 65

Statistical adjustment may be needed for the lower portions of patients older than 65, and patients with stays shorter than 10 days Corrigan et al., 2011
The Traumatic Brain Injury Model Systems (TBIMS) Built by the National Institute on Disability and Rehabilitation Research (NIDRR)


The NIDRR Long Range Plan





Promotes health and function

Promotes independent living

Improves community integration Hammond & Malec, 2010
HIV HIVBrainSeqDB: The HIV Brain Sequence Database To study:

HIV replications in a host

HIV independently evolving

Genetic differences

HIV replication in the brain

Neurocognitive disorders in about 1/3 of patients

Drug resistance problems

The basic determinants of HIV neurotropism

Macrophage tropism and the viral envelope (env) gene

HIV sequence databases needed to collect data on neurotropic virus

Neurocognitive and neuropathological information needed

An online database of HIV envelope sequences

Sequences are from the brain and tissues from the same individuals

Sequences are annotated with clinical data and curated from publications

An anatomical ontology – The Foundational Model of Anatomy

Tissue types are divided into several categories (Brain, brainstem, and spinal cord; Meninges, choroid plexus, and CSF; Blood and lymphoid; etc.)

Envelope sequences from individuals

Patient coding is related

Sequences from the same individual can be grouped

Cytoscape was used

Interconnections across studies, patient number, and tissue representation

The visualization of the associations between studies, patients and sequences

Real-time searches, multiple parameters

Studies of the genetic aspects of HIV macrophage tropism

Analyses of HIV compartmentalization and evolution in the brain

Associations with HIV-associated neurological disorders Holman et al., 2010




Hall, D., Huerta, M. F., McAuliffe, M. J., & Farber, G. K. (2012). Sharing Heterogeneous Data: The National Database for Autism Research. Neuroinformatics. doi:10.1007/s12021-012-9151-4

Neumann, J.-O., Chambers, I. R., Citerio, G., Enblad, P., Gregson, B. A., Howells, T., … Kiening, K. (2008). The use of hyperventilation therapy after traumatic brain injury in Europe: an analysis of the BrainIT database. Intensive care medicine, 34(9), 1676–1682. doi:10.1007/s00134-008-1123-7

Corrigan, J. D., Cuthbert, J. P., Whiteneck, G. G., Dijkers, M. P., Coronado, V., Heinemann, A. W., … Graham, J. E. (2011). Representativeness of the Traumatic Brain Injury Model Systems National Database. The Journal of head trauma rehabilitation. doi:10.1097/HTR.0b013e3182238cdd

Hammond, F. M., & Malec, J. F. (2010). The Traumatic Brain Injury Model Systems: a longitudinal database, research, collaboration and knowledge translation. European journal of physical and rehabilitation medicine, 46(4), 545–548. Retrieved from

Holman, A. G., Mefford, M. E., O’Connor, N., & Gabuzda, D. (2010). HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites. AIDS research and therapy, 7, 43. doi:10.1186/1742-6405-7-43

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