Category Archives: Neuroinformatics

Neuroinformatics, computational neuroscience

Microglia, Polydendrocytes, Ependymal cells, and the Embryonic Neural Tube

Microglia are macrophages in the brain. Macrophages are the immune cells in the blood and other parts of the body. Microglia can be activated upon neuronal damages or infections, to destroy foreign stuff or pathogens, as well as necrotic tissues. … Continue reading

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Glia, Astrocytes, Oligodendrocytes, and Schwann Cells

Glia have a close relationship with neurons but this relationship has not been fully understood. Glia are essential partners to neurons and may influence many functions including neuronal and metabolic activities, neurotransmitter kinetics, as well as the blood flow. Glial … Continue reading

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Synapses, Gap Junctions, and Glia: Their Structures, Functions, and Features

Synapses are the regions between the terminal of an axon and the receptors on other cells. Neurotransmitters can bring the messages across the synapses. Synapses can be open or enclosed, large or small. Synaptic inputs can affect the neuron activities. … Continue reading

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Neurotransmitters and Their Functions

There are different types of neurotransmitters. For example, glutamate (glu) is involved in the excitation of the central nervous system (CNS). Aspartate (asp) is involved in the excitation of the brain and spinal cord. Gama-aminobutyric acid (GABA) is involved in … Continue reading

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Structure of the Neurons: Dendrites, Axons, and Membrane Potentials

Types of cells in the nervous system There are two types of cells in the nervous system. One type of cells are called neurons, the other type of cells are called glia. Studies have found that there are about 86 … Continue reading

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Neuroscience Data and Neuroinformatics

Neuroscience Data and Neuroinformatics   Neuroscience Data   At least 50% genes of the mammalian genome are expressed by the nervous system (Sutcliffe et al., 1991). To understand brain-related diseases, it is necessary to map and study the expression patterns … Continue reading

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The Applications and Combination of Bioinformatics, Medical informatics, and Neuroinformatics

The Applications and Combination of Bioinformatics, Medical informatics, and Neuroinformatics   Mental disorders and other brain disorders such as anxiety, depression, schizophrenia, and visual impairments may account for at least one third of the worldwide burden of diseases (Wittchen et … Continue reading

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Neuroinformatics Software and Ontology Tools

Neuroinformatics Software and Ontology Tools     Category Source Name Purposes/Features/Methods Contents Applications URL References Neuroimaging Informatics Tools BrainVisa (BV) For high resolution MR images To quantify global and regional variances About cortical anatomy A plug-in application for structural analysis … Continue reading

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Neuroinformatics Databases about the Brain: Different Species

Neuroinformatics Databases about the Brain: Different Species   Species Source Name Purposes/Features/Methods Contents Applications URL References Mouse 3D digital atlas database of the mouse brain Lower spatial resolution images were utilized to enhance time efficiency for morphological phenotyping The in … Continue reading

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Neuroinformatics Databases about the Brain-Related Diseases

Neuroinformatics Databases about the Brain-Related Diseases Disease Source Name Purposes/Features/Methods Contents Applications URL References Autism National Database for Autism Research (NDAR) A secure database for data sharing, data harmonization, and collaboration in autism spectrum disorder researchers Data from more than … Continue reading

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Neuroinformatics Databases for the Structure-Function Studies of the Brain

Neuroinformatics Databases for the Structure-Function Studies of the Brain     Category Source Name The Needs/Challenges Purposes/Features/Methods Contents Applications URL References Neuroinformatics Databases about the Brain Structures The Internet Brain Volume Database (IBVD) Available data from neuroanatomic volumetric measurements; Various … Continue reading

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Neuroinformatics Databases about the Brain Structures

Neuroinformatics Databases about the Brain Structures   The Internet Brain Volume Database (IBVD) (Kennedy et al., 2012) The URL: http://www.nitrc.org/projects/ibvd The background Publications available about Neuroanatomic volumetric observations Large data sets of volumetric measurements with variables of Specific species Structures … Continue reading

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Neuroinformatics: An Introduction

Neuroinformatics: An Introduction The challenges in neuroinformatics   Challenges in making neuroinformatics databases and tools (Morse, 2008) The variety in spatial scales Various data types Traditional bioinformatics concentrates on Genomic and proteomic data Sequences (DNA, RNA, and protein molecules) Development … Continue reading

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