Whole Grain Cereal, Obesity, and the PI3K/Akt Pathway

Whole grain cereal contains fibers, minerals, vitamins, and phytochemicals. Whole grain cereal has been found to inhibit body weight gain and non-alcoholic fatty liver (Lee et al., 2017).

Whole grain cereal could decrease the atrophy-associated factors, fat pad mass, and adipocyte size (Lee et al., 2017). The phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway may be involved in muscle hypertrophy and myogenesis. Whole grain cereal could enhance the PI3K/Akt pathway activities and the regulators of muscle hypertrophy and myogenesis.

Therefore, whole grain cereal has been suggested as beneficial for relieving obesity-induced muscle atrophy and the overall obesity (Lee et al., 2017).

Lee S, Kim MB, Kim C, Hwang JK. Whole grain cereal attenuates obesity-induced muscle atrophy by activating the PI3K/Akt pathway in obese C57BL/6N mice. Food Sci Biotechnol. 2017 Dec 12;27(1):159-168. doi: 10.1007/s10068-017-0277-x.

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