The Database of Biomarkers: Proteomic and Pathway Biomarkers

  • Associated diseases/conditions:

Depression

 

Potential Biomarkers:

“Tumor Necrosis Factor (TNF) and its targets in the inflammatory cytokine pathway”

 

Detections:

Protein expressions

 

Potential Applications:

“Predictive biomarkers for treatment response (to the selective serotonin reuptake inhibitor (SSRI) antidepressant escitalopram)”

 

References:

Powell TR, Schalkwyk LC, Heffernan AL, Breen G, Lawrence T, Price T, Farmer AE, Aitchison KJ, Craig IW, Danese A, Lewis C, McGuffin P, Uher R, Tansey KE, D’Souza UM. Tumor Necrosis Factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response. Eur Neuropsychopharmacol. 2013 Sep;23(9):1105-14. doi: 10.1016/j.euroneuro.2012.09.009. (http://www.ncbi.nlm.nih.gov/pubmed/23142150)

 

  • Associated diseases/conditions:

Multiple sclerosis (MS)

 

Potential Biomarkers:

c-Jun N-terminal kinase (JNK) -dependent apoptosis pathway

 

Detections:

Gene expression, peripheral blood mononuclear cells (PBMCs)

 

Potential Applications:

“Diagnostic biomarkers in the active phase of relapsing-remitting MS (RRMS)”

 

References:

Ferrandi C, Richard F, Tavano P, Hauben E, BarbiƩ V, Gotteland JP, Greco B, Fortunato M, Mariani MF, Furlan R, Comi G, Martino G, Zaratin PF. Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers. Mult Scler. 2011 Jan;17(1):43-56. doi: 10.1177/1352458510381258. (http://www.ncbi.nlm.nih.gov/pubmed/20855355)

 

  • Associated diseases/conditions:

Cardiovascular disease (CVD)

 

Potential Biomarkers:

Osteoprotegerin (OPG) pathway

 

Detections:

Protein serum concentrations

 

Potential Applications:

“Predictive biomarkers for CVD risk factor burden and mortality”

 

References:

Lieb W, Gona P, Larson MG, Massaro JM, Lipinska I, Keaney JF Jr, Rong J, Corey D, Hoffmann U, Fox CS, Vasan RS, Benjamin EJ, O’Donnell CJ, Kathiresan S. Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1849-54. doi: 10.1161/ATVBAHA.109.199661. (http://www.ncbi.nlm.nih.gov/pubmed/20448212)

 

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