The Database of Biomarkers: MicroRNA Biomarkers

December 9, 2013
by Pharm Tao

The Database of Biomarkers: MicroRNA Biomarkers

•    Associated diseases/conditions:
Obesity and type 2 diabetes

Potential Biomarkers:
Serum miR-138, miR-15b, miR-376a (obesity); combination of miR-503 and miR-138 (diabetes)

Potential Applications:
Predictive biomarkers

References:
Pescador N, Pérez-Barba M, Ibarra JM, Corbatón A, Martínez-Larrad MT, Serrano-Ríos M. Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers. PLoS One. 2013 Oct 15;8(10):e77251. doi: 10.1371/journal.pone.0077251. (http://www.ncbi.nlm.nih.gov/pubmed/24204780)

•    Associated diseases/conditions:
Parkinson’s disease (PD)

Potential Biomarkers:
Plasma k-TSP1 (miR-1826/miR-450b-3p), miR-626, and miR-505

Potential Applications:
Predictive biomarkers

References:
Khoo SK, Petillo D, Kang UJ, Resau JH, Berryhill B, Linder J, Forsgren L,
Neuman LA, Tan AC. Plasma-based circulating MicroRNA biomarkers for Parkinson’s disease. J Parkinsons Dis. 2012;2(4):321-31. doi: 10.3233/JPD-012144. (http://www.ncbi.nlm.nih.gov/pubmed/23938262)

•    Associated diseases/conditions:
Rheumatoid arthritis (RA)

Potential Biomarkers:
Plasma miR-24 and miR-125a-5p

Potential Applications:
Diagnostic biomarkers

References:
Murata K, Furu M, Yoshitomi H, Ishikawa M, Shibuya H, Hashimoto M, Imura Y, Fujii T, Ito H, Mimori T, Matsuda S. Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis. PLoS One. 2013 Jul 18;8(7):e69118. doi: 10.1371/journal.pone.0069118. (http://www.ncbi.nlm.nih.gov/pubmed/23874885)

•    Associated diseases/conditions:
Chronic active Epstein-Barr virus (CAEBV) infection

Potential Biomarkers:
Plasma miR-BART2-5p, 13, and 15

Potential Applications:
Disease severity or prognostic biomarkers

References:
Kawano Y, Iwata S, Kawada J, Gotoh K, Suzuki M, Torii Y, Kojima S, Kimura H, Ito Y. Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection. J Infect Dis. 2013 Sep 1;208(5):771-9. doi:  10.1093/infdis/jit222. (http://www.ncbi.nlm.nih.gov/pubmed/23687223)

•    Associated diseases/conditions:
Kidney injury

Potential Biomarkers:
Urinary miR-10a and miR-30d

Potential Applications:
Diagnostic biomarkers

References:
Wang N, Zhou Y, Jiang L, Li D, Yang J, Zhang CY, Zen K. Urinary microRNA-10a and microRNA-30d serve as novel, sensitive and specific biomarkers for kidney injury. PLoS One. 2012;7(12):e51140. doi: 10.1371/journal.pone.0051140. (http://www.ncbi.nlm.nih.gov/pubmed/23272089)

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