The Database of Biomarkers: MicroRNA Biomarkers – Psychiatric Disorders

The Database of Biomarkers: MicroRNA Biomarkers – Psychiatric Disorders

•    Associated diseases/conditions:
Mild Cognitive Impairment (MCI), age-related brain changes

Potential Biomarkers:
Brain-enriched plasma the “miR-132 family” (miR-128/miR-491-5p, miR-132/miR-491-5p and mir-874/miR-491-5p) and the “miR-134 family” (miR-134/miR-370, miR-323-3p/miR-370 and miR-382/miR-370)

Potential Applications:
Early diagnostic biomarkers (“at asymptomatic stage 1-5 years prior to clinical diagnosis”)

References:
Sheinerman KS, Tsivinsky VG, Crawford F, Mullan MJ, Abdullah L, Umansky SR. Plasma microRNA biomarkers for detection of mild cognitive impairment. Aging (Albany NY). 2012 Sep;4(9):590-605. (http://www.ncbi.nlm.nih.gov/pubmed/23001356)

•    Associated diseases/conditions:
Schizophrenia

Potential Biomarkers:
Peripheral blood hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652

Potential Applications:
Diagnostic biomarkers

References:
Lai CY, Yu SL, Hsieh MH, Chen CH, Chen HY, Wen CC, Huang YH, Hsiao PC, Hsiao
CK, Liu CM, Yang PC, Hwu HG, Chen WJ. MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia. PLoS One. 2011;6(6):e21635. doi: 10.1371/journal.pone.0021635. (http://www.ncbi.nlm.nih.gov/pubmed/21738743)

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