The Database of Biomarkers: MicroRNA Biomarkers – Cardiovascular Diseases

The Database of Biomarkers: MicroRNA Biomarkers – Cardiovascular Diseases

•    Associated diseases/conditions:
Atherosclerosis and stroke

Potential Biomarkers:
Serum miR-21 and miR-221

Potential Applications:
Predictive biomarkers

References:
Tsai PC, Liao YC, Wang YS, Lin HF, Lin RT, Juo SH. Serum microRNA-21 and microRNA-221 as potential biomarkers for cerebrovascular disease. J Vasc Res. 2013;50(4):346-54. doi: 10.1159/000351767. (http://www.ncbi.nlm.nih.gov/pubmed/23860376)

•    Associated diseases/conditions:
Myocardial injury in open-heart surgeries with cardiopulmonary bypass (CPB)

Potential Biomarkers:
Serum and urine miR-1

Potential Applications:
Diagnostic biomarker

References:
Zhou X, Mao A, Wang X, Duan X, Yao Y, Zhang C. Urine and serum microRNA-1 as novel biomarkers for myocardial injury in open-heart surgeries with cardiopulmonary bypass. PLoS One. 2013 Apr 22;8(4):e62245. doi: 10.1371/journal.pone.0062245. (http://www.ncbi.nlm.nih.gov/pubmed/23630629)

•    Associated diseases/conditions:
Acute myocardial infarction (AMI)

Potential Biomarkers:
Peripheral blood miR-1291 and miR-663b (disease markers); miR-30c and miR-145 (markers of infarct sizes)

Potential Applications:
Diagnostic biomarkers

References:
Meder B, Keller A, Vogel B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Just S, Borries A, Rudloff J, Leidinger P, Meese E, Katus HA, Rottbauer W. MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction. Basic Res Cardiol. 2011 Jan;106(1):13-23. doi: 10.1007/s00395-010-0123-2. (http://www.ncbi.nlm.nih.gov/pubmed/20886220)

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