The Database of Biomarkers: Depression – Proteomic and Pathway Biomarkers

•    Potential Biomarkers:
The tryptophan-kynurenine pathway

Detections:
Increased indoleamine 2,3-dioxygenase activity

Potential Applications:
Diagnostic biomarkers

References:
Christmas DM, Potokar J, Davies SJ. A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase. Neuropsychiatr Dis Treat. 2011;7:431-9. doi: 10.2147/NDT.S17573. (http://www.ncbi.nlm.nih.gov/pubmed/21792309)

•    Potential Biomarkers:
The kynurenine pathway

Detections:
Tryptophan hydroxylase 2 (TPH2), kynurenine 3 monooxygenase (KMO) and kynurenine amino transferase 3 (KAT III) SNPs

Potential Applications:
Diagnostic biomarkers

References:
Claes S, Myint AM, Domschke K, Del-Favero J, Entrich K, Engelborghs S, De Deyn P, Mueller N, Baune B, Rothermundt M. The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes. Psychiatry Res. 2011 Aug 15;188(3):355-60. doi: 10.1016/j.psychres.2011.03.012. (http://www.ncbi.nlm.nih.gov/pubmed/21492941)

•    Potential Biomarkers:
The kynurenine pathway (KP)

Detections:
Kynurenine (KYN) / tryptophan (TRP) ratios

Potential Applications:
Diagnostic biomarkers for adolescents with melancholic features-major depressive disorder (M-MDD)

References:
Gabbay V, Klein RG, Katz Y, Mendoza S, Guttman LE, Alonso CM, Babb JS, Hirsch  GS, Liebes L. The possible role of the kynurenine pathway in adolescent depression with melancholic features. J Child Psychol Psychiatry. 2010 Aug;51(8):935-43. doi: 10.1111/j.1469-7610.2010.02245.x. (http://www.ncbi.nlm.nih.gov/pubmed/20406333)

•    Potential Biomarkers:
The CREB1-BDNF-NTRK2 pathway

Detections:
BDNF-rs6265 and CREB1-rs2253206

Potential Applications:
Diagnostic biomarkers

References:
Juhasz G, Dunham JS, McKie S, Thomas E, Downey D, Chase D, Lloyd-Williams K, Toth ZG, Platt H, Mekli K, Payton A, Elliott R, Williams SR, Anderson IM, Deakin JF. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry. 2011 Apr 15;69(8):762-71. doi: 10.1016/j.biopsych.2010.11.019. (http://www.ncbi.nlm.nih.gov/pubmed/21215389)

•    Potential Biomarkers:
The canonical Wnt signaling pathway

Detections:
Polymorphisms in GSK3beta

Potential Applications:
Diagnostic biomarkers

References:
Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. Neuroimage. 2010 Nov 15;53(3):908-17. doi: 10.1016/j.neuroimage.2010.02.065. (http://www.ncbi.nlm.nih.gov/pubmed/20219685)

•    Potential Biomarkers:
Neurodegeneration-neurofilament protein light (NFL), amyloid beta-42 (Abeta42), and CSF/serum albumin ratio; T-tau and P-tau

Detections:
Cerebrospinal fluid (CSF) proteins

Potential Applications:
Diagnostic biomarkers of neuropathological and vascular events in depression etiology vs Alzheimer’s disease

References:
Gudmundsson P, Skoog I, Waern M, Blennow K, Zetterberg H, Rosengren L, Gustafson D. Is there a CSF biomarker profile related to depression in elderly women? Psychiatry Res. 2010 Apr 30;176(2-3):174-8. doi: 10.1016/j.psychres.2008.11.012. (http://www.ncbi.nlm.nih.gov/pubmed/20132991)

Reis T, Brandão CO, Freire Coutinho ES, Engelhardt E, Laks J. Cerebrospinal fluid biomarkers in Alzheimer’s disease and geriatric depression: preliminary findings from Brazil. CNS Neurosci Ther. 2012 Jul;18(7):524-9. doi: 10.1111/j.1755-5949.2012.00311.x. (http://www.ncbi.nlm.nih.gov/pubmed/22530600)

•    Potential Biomarkers:
Sputum interleukin (IL)-6, tumor necrosis factor (TNF)-α and flattened diurnal salivary cortisol slopes

Detections:
Sputum and salivary

Potential Applications:
Diagnostic biomarkers of depression in lung cancer patients

References:
Du YJ, Zhang HY, Li B, Wu X, Lv YB, Jin HL, Cao YX, Sun J, Luo QL, Gong WY, Liu BJ, Wu JF, Shi SX, Dong JC. Sputum interleukin-6, tumor necrosis factor-α and Salivary cortisol as new biomarkers of depression in lung cancer patients. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec;47:69-76. doi: 10.1016/j.pnpbp.2013.08.004. (http://www.ncbi.nlm.nih.gov/pubmed/23969030)

Leave a Reply

Copyright © 2006-2017 PharmTao.com. All Rights Reserved.

Disclaimer: By using this site, the readers agree that the content on our web pages is for information purpose only. The information provided on our web pages is not intended for diagnosis, or to treat, cure or prevent any diseases, conditions or symptoms, or to endorse any products. Personal directions and the use of health products should be provided by qualified health professionals.

Mind-Body, Personalized, and Systems Medicine