The Database of Biomarkers: Depression – MicroRNA Biomarkers

•    Potential Biomarkers:
miR-30e, the polymorphism ss178077483

Potential Applications:
Diagnostic biomarker for major depressive disorder (MDD) risks

References:
Xu Y, Liu H, Li F, Sun N, Ren Y, Liu Z, Cao X, Wang Y, Liu P, Zhang K. A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform. J Affect Disord. 2010 Dec;127(1-3):332-6. doi: 10.1016/j.jad.2010.05.019. (http://www.ncbi.nlm.nih.gov/pubmed/20579744)

•    Potential Biomarkers:
pre-miR-182, the polymorphism rs76481776

Potential Applications:
Diagnostic biomarker for MDD patients with insomnia

References:
Saus E, Soria V, Escaramís G, Vivarelli F, Crespo JM, Kagerbauer B, Menchón JM, Urretavizcaya M, Gratacòs M, Estivill X. Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia. Hum Mol Genet. 2010 Oct 15;19(20):4017-25. doi: 10.1093/hmg/ddq316. (http://www.ncbi.nlm.nih.gov/pubmed/20656788)

•    Potential Biomarkers:
miR-16

Potential Applications:
SSRI response biomarkers

References:
Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O. miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science. 2010 Sep 17;329(5998):1537-41. doi: 10.1126/science.1193692. (http://www.ncbi.nlm.nih.gov/pubmed/20847275)

•    Potential Biomarkers:
miR-132 and miR-182, brain-derived neurotrophic factor (BDNF)

Potential Applications:
Diagnostic biomarkers

References:
Li YJ, Xu M, Gao ZH, Wang YQ, Yue Z, Zhang YX, Li XX, Zhang C, Xie SY, Wang PY. Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS One. 2013 May 21;8(5):e63648. doi: 10.1371/journal.pone.0063648. (http://www.ncbi.nlm.nih.gov/pubmed/23704927)

•    Potential Biomarkers:
miR-151-3p, miR-212, miR-132, miR-30b*, let-7b and let-7c

Potential Applications:
SSRI response biomarkers

References:
Oved K, Morag A, Pasmanik-Chor M, Oron-Karni V, Shomron N, Rehavi M, Stingl JC, Gurwitz D. Genome-wide miRNA expression profiling of human lymphoblastoid cell lines identifies tentative SSRI antidepressant response biomarkers. Pharmacogenomics. 2012 Jul;13(10):1129-39. doi: 10.2217/pgs.12.93. (http://www.ncbi.nlm.nih.gov/pubmed/22909203)

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