The Database of Biomarkers: Depression – fMRI Biomarkers

•    Potential Biomarkers:
Activation patterns: “greater and more sustained signals in three regions: BA24 (dorsal anterior cingulate), BA31 (posterior cingulate), and BA6 (prefrontal cortex)”

Potential Applications:
Diagnostic biomarkers in late-life anxious depression (LLAD)

References:
Andreescu C, Butters M, Lenze EJ, Venkatraman VK, Nable M, Reynolds CF 3rd, Aizenstein HJ. fMRI activation in late-life anxious depression: a potential biomarker. Int J Geriatr Psychiatry. 2009 Aug;24(8):820-8. doi: 10.1002/gps.2327. (http://www.ncbi.nlm.nih.gov/pubmed/19575412)

•    Potential Biomarkers:
“The functional neuroanatomy of verbal working memory”

Potential Applications:
Diagnostic biomarker

References:
Marquand AF, Mourão-Miranda J, Brammer MJ, Cleare AJ, Fu CH. Neuroanatomy of verbal working memory as a diagnostic biomarker for depression. Neuroreport. 2008 Oct 8;19(15):1507-11. doi: 10.1097/WNR.0b013e328310425e. (http://www.ncbi.nlm.nih.gov/pubmed/18797307)

•    Potential Biomarkers:
Regional brain atrophy: “volumetric reduction in the orbitofrontal cortex bilaterally”

Potential Applications:
Diagnostic and predictive biomarkers of outcomes

References:
Ribeiz SR, Duran F, Oliveira MC, Bezerra D, Castro CC, Steffens DC, Busatto Filho G, Bottino CM. Structural brain changes as biomarkers and outcome predictors in patients with late-life depression: a cross-sectional and prospective study. PLoS One. 2013 Nov 14;8(11):e80049. doi: 10.1371/journal.pone.0080049. (http://www.ncbi.nlm.nih.gov/pubmed/24244606)

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