The Database of Biomarkers: Depression – Epigenetic Biomarkers

•    Potential Biomarkers:
“DNA methylation profiles of CpG I at the promoters of the brain-derived neurotrophic factor (BDNF)”

Potential Applications:
Diagnostic biomarker

References:
Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N, Inoue T, Kusumi I, Koyama T, Tsuchiyama K, Terao T. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS One. 2011;6(8):e23881. doi: 10.1371/journal.pone.0023881.
(http://www.ncbi.nlm.nih.gov/pubmed/21912609)

Launay JM, Mouillet-Richard S, Baudry A, Pietri M, Kellermann O. Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16. Transl Psychiatry. 2011 Nov 22;1:e56. doi: 10.1038/tp.2011.54.
(http://www.ncbi.nlm.nih.gov/pubmed/22833211)

•    Potential Biomarkers:
“Serotonin transporter gene (SLC6A4) DNA promoter methylation”

Potential Applications:
Diagnostic and prognostic biomarker for poststroke depression (PSD)

References:
Kang HJ, Kim JM, Stewart R, Kim SY, Bae KY, Kim SW, Shin IS, Shin MG, Yoon JS. Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul;44:23-8. doi: 10.1016/j.pnpbp.2013.01.006.  (http://www.ncbi.nlm.nih.gov/pubmed/23333376)

Kim JM, Stewart R, Kang HJ, Kim SW, Shin IS, Kim HR, Shin MG, Kim JT, Park MS, Cho KH, Yoon JS. A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression. J Psychiatr Res. 2013 Sep;47(9):1222-7. doi: 10.1016/j.jpsychires.2013.04.010. (http://www.ncbi.nlm.nih.gov/pubmed/23702251)

•    Potential Biomarkers:
“The angiotensin converting enzyme (ACE) promoter DNA methylation”

Potential Applications:
“Diagnostic biomarker and bi-directional relationship between major depression (MD) and cardiovascular disorders”

References:
Zill P, Baghai TC, Schüle C, Born C, Früstück C, Büttner A, Eisenmenger W, Varallo-Bedarida G, Rupprecht R, Möller HJ, Bondy B. DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. PLoS One. 2012;7(7):e40479. doi: 10.1371/journal.pone.0040479. (http://www.ncbi.nlm.nih.gov/pubmed/22808171)

•    Potential Biomarkers:
“Higher DNA methylation in the promoter region of P11 (S100A10)”

Potential Applications:
“Diagnostic biomarkers and predictive biomarker of antidepressant treatment responses”

References:
Melas PA, Rogdaki M, Lennartsson A, Björk K, Qi H, Witasp A, Werme M, Wegener  G, Mathé AA, Svenningsson P, Lavebratt C. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Int J Neuropsychopharmacol. 2012 Jun;15(5):669-79. doi: 10.1017/S1461145711000940. (http://www.ncbi.nlm.nih.gov/pubmed/21682946)

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