The Database of Biomarkers: Depression – EEG Biomarkers

•    Potential Biomarkers:
“Midline and right frontal (MRF) cortical area,  early decreases in theta-band cordance”

Potential Applications:
Predictive biomarker of remission in major depressive disorder (MDD)

References:
Cook IA, Hunter AM, Abrams M, Siegman B, Leuchter AF. Midline and right frontal brain function as a physiologic biomarker of remission in major depression. Psychiatry Res. 2009 Nov 30;174(2):152-7. doi: 10.1016/j.pscychresns.2009.04.011. (http://www.ncbi.nlm.nih.gov/pubmed/19853417)

•    Potential Biomarkers:
Sleep abnormalities: “combined features of increased rapid eye movement (REM) density and shortened slow-wave sleep (SWS)”

Potential Applications:
Diagnostic and predictive biomarkers for major depressive disorder (MDD) and remission

References:
Pillai V, Kalmbach DA, Ciesla JA. A meta-analysis of electroencephalographic sleep in depression: evidence for genetic biomarkers. Biol Psychiatry. 2011 Nov 15;70(10):912-9. doi: 10.1016/j.biopsych.2011.07.016. (http://www.ncbi.nlm.nih.gov/pubmed/21937023)

•    Potential Biomarkers:
Wake and sleep patterns: “prefrontal quantitative EEG cordance; impaired sleep continuity, desinhibition of REM sleep and changes of nonREM sleep”

Potential Applications:
Diagnostic and predictive biomarkers of depression and antidepressant responses

References:
Steiger A, Kimura M. Wake and sleep EEG provide biomarkers in depression. J Psychiatr Res. 2010 Mar;44(4):242-52. doi: 10.1016/j.jpsychires.2009.08.013. (http://www.ncbi.nlm.nih.gov/pubmed/19762038)

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