The Antiviral Flavonoids for SARS-CoV and HCV

The Antiviral Flavonoids for SARS-CoV and HCV

(From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets)

  • Aryl diketoacid (ADK) has antiviral effects that can be improved by adding an aromatic arylmethyl substituent (Park et al., 2012).
  • A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore.
  • It is in association with the 1,3-diketoacid moiety of the ADK (Park et al., 2012).
  • It is necessary to examine the antiviral effects of the quercetin derivatives with an arylmethyl group attached.
  • Some 7-O-arylmethylquercetin derivatives with aromatic substituents were assessed for their antiviral effects (Park et al., 2012).
  • The effects were examined against the SARS-CoV and hepatitis C virus (HCV).
  • Aromatic substituents improved the effects of the 7-O-arylmethylquercetin derivatives against SCV and HCV (Park et al., 2012).

References:

Park, H. R., Yoon, H., Kim, M. K., Lee, S. D., & Chong, Y. (2012). Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV). Archives of Pharmacal Research, 35(1), 77–85.

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