Tag Archives: Systems Biology

Translational Medicine and Drug Discovery

Recent development in translational medicine provides a connection between basic scientific studies and clinical practice. Such an initiative may support the patient-centered objectives in both research and clinical environments. It may also improve the drug discovery procedure by allowing for … Continue reading

Posted in Systems Biology, Systems Medicine | Tagged , , , , , , , , , , , | Leave a comment

Systems Biology Approaches and Drug Design

The reductionist way of “one gene-one disease-one drug” has made it difficult for the discovery of more effective drugs.  In addition to conventional phenotypic and drug target screens, new methodologies may improve the drug design process, including ligand- and structure-based … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , | Leave a comment

Genetic Networks and Biomarkers

The post-genomic research based on large cohorts of preclinical studies have produced multi-dimensional genetic and transcriptomic data sets. The revelation of the molecular pathways and cellular networks associated with various diseases may promote the systems biology studies of the onset … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , | Leave a comment

Systems Biology and Companion Diagnostics

The development in high-throughput (HTP) technologies and computational biology may help define the next generation of biomarkers. By providing an integrative viewpoint, systems biology may improve the understanding of the complexity in biological systems. The assemblage of interacting molecular elements … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , | Leave a comment

Biomarkers for Inflammatory Breast Cancer

Inflammatory breast cancer (IBC) is an aggressive type of breast cancers (BC). Currently only a few specific genetic biomarkers or signatures have been identified for the disease. However, these genetic signatures are not very representative (Remo et al. 2015). More … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , | Leave a comment

Challenges in Biomarker Discovery

Although biomarkers have been considered more and more important, it is still very difficult to identify and validate effective and useful biomarkers. The obstacles in the biomarker identification include both technical and theoretical reasons. For example, methods for identifying pathology-type … Continue reading

Posted in Biomarkers, Systems Biology | Tagged , , , , , , , , , | Leave a comment

Biomarkers of Seasonal Allergic Rhinitis (SAR)

Seasonal allergic rhinitis (SAR) is not just a commonly seen health problem in certain seasons. It is also a risk factor that can lead to asthma among many people. Nasal allergies can promote bone-marrow eosinophil generation through cytokines such as … Continue reading

Posted in Biomarkers, Systems Biology | Tagged , , , , , , , , , | Leave a comment

Systems Biology and Biomarkers in Neuropsychiatry

Neuropsychiatric (NP) disorders such as autism spectrum disorders (ASD) are the leading causes of disability around the world. However, because of their complexity, the etiology and pathophysiology of NP diseases are still mostly unknown. Such complexity may be caused by … Continue reading

Posted in Biomarkers, Systems Biology | Tagged , , , , , , , , , | Leave a comment

Biomarkers, Oncology, and Precision Medicine

The identification of biomarkers is becoming more and more important in biomedicine, especially for the clinical practice. This is because biomarkers often contain valuable information about the pathology of the diseases such as cancers. Such information is useful for better … Continue reading

Posted in Biomarkers, Systems Biology | Tagged , , , , , , , , , | Leave a comment

Systems Biology Technologies and Cancer Immunotherapy

Decades of scientific studies have demonstrated the essential role of the immune system in cancer pathology and clinical treatment. The immune system may regulate the growth of tumors via the complex interactions among molecules, genes, cells, and organs. The elucidation … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , , , , | Leave a comment

Skin Disorders, Skinomics and Microarray Studies

The new field of “skinomics” refers to the use of systems biology and “omics” approaches in the studies of the skin and dermatology. For example, high-through put (HTP) methods such as microarrays have been applied to identify biomarkers including transcriptional … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , | Leave a comment

Systems Biomarkers and Skin Diseases

With the development of systems biology, bioinformatics, ‘omics’ studies, more and more discoveries are made in the disorders including cardiovascular diseases and cancer. However, although sometimes ignored, other common illnesses with high incidences including skin diseases also need more assessments … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , | Leave a comment

Systems Biology, Immunity, Biomarkers, and Aging

Many chronic diseases are age-associated, including Alzheimer’s disease, cardiovascular disease, type 2 diabetes, and cancer. The elevating incidence of these disorders asks for the better understanding of the associations between the aging process and various diseases. With the increasing life … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , , , | Leave a comment

Systems Biology, Lipidomics, and Cardiovascular Disease

Atherosclerosis involves a gradual process of inflammation with the stiffening of the arterial wall. This inflammatory condition can be caused by many factors, including elevated cellularity, lipid accrual, cellular debris, as well as extracellular substances (De Leon et al., 2015). … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , , , , | Leave a comment

Network Interactions, Interactomes, and Drug Discovery

Because genes and proteins are functioning in complex networks and interactions, one molecule may influence other cellular elements in a broad range. These interactions can be studied in “interactomes”, a term referring to the protein-protein interaction networks (Chautard et al., … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , , , | Leave a comment

Systems Biology and Neurodegenerative Diseases

Neurodegenerative diseases (NDs) are complex disorders that affect more than 40 million people globally (Wood et al., 2015). The multifaceted variations in the pathophysiology of the diseases make it difficult for effective therapy or prevention of the disease progression. More … Continue reading

Posted in Psychiatric Genetics, Systems Biology | Tagged , , , , , , , , , , | Leave a comment

Systems Biology and Drug Screening

Conventional drug design mostly uses the ligand and structure-based approaches (Prathipati and Mizuguchi, 2015). With the advancement in functional genomics and the availability of high-throughput (HTP) data, information on interactive molecular networks can be used to analyze the efficacy and … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , | Leave a comment

The Circadian Clock, Genes, and Systems Biology

The circadian clock is essential in many organisms. The circadian timing system enables the physiological and behavioral adaptation to the external geophysical changes through the regulation of the temporal cellular processes (Lehmann et al., 2015). In mammals, the master pacemaker … Continue reading

Posted in Chronobiology, Systems Biology | Tagged , , , , , , , , , , , | Leave a comment

Systems Biology and Subnetworks in Breast Cancer

As a complex disease with heterogeneous factors involved, breast cancer have various subtypes with distinct therapeutic response patterns and outcomes (Yersal and Barutca, 2014). Conventional classification systems of breast cancer have limitations in describing such features. In order to achieve … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , , , | Leave a comment

Systems Biology, miRNAs, and Alzheimer’s Disease

Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial involving genomics, metabolomics, epigenomics, transcriptomics, interactomics, as well as environmental components. Systemic understanding of these complex diseases may start with the alterations in the cellular networks. Investigation in integrative systems biology … Continue reading

Posted in Psychiatric Genetics, Systems Biology | Tagged , , , , , , , , , , , , , | Leave a comment

Nutritional Systems Biology and Type 2 Diabetes

Systems biology studies include the investigations in various “omics” areas, such as genomics, transcriptomics, proteomics, metabolomics, epigenomics, as well as microbiomics. Combining both computational and experimental biology, systems biology aims at prediction of the dynamical processes and the description of … Continue reading

Posted in Systems Biology | Tagged , , , , , , , , , , , , | Leave a comment

The integration of various “omics” technologies in systems biology for better diagnosis and treatment

With the advancements in the “omics” technologies and the information technology, systems biology has become an important approach for biomarker discovery. These technologies allow faster and cheaper analyses of gene expression, protein interactions, signaling pathways, and metabolic mechanisms. In this … Continue reading

Posted in Systems Biology, Systems Medicine | Tagged , , , , , , , , , , , , , , | Leave a comment

Systems biology approaches for the pharmacokinetic/pharmacodynamic (PK/PD) modeling in drug discovery and development

Systems biology-enabled computational modeling can be useful in almost every step of drug discovery and development, including drug target identification and clinical outcome analysis. Various modeling strategies can be used at different stages. For example, during the basic scientific research … Continue reading

Posted in Systems Biology, Systems Medicine | Tagged , , , , , , , , , | Leave a comment

Systems biology strategies are useful for biomarker identification in traumatic brain injury (TBI)

The identification of biomarkers may have a significant influence on patient care. Biomarkers may be used for better diagnosis, disease profiling, research design, and drug target discovery. For instance, biomarkers have been considered to be critical in the management of … Continue reading

Posted in Systems Biology, Systems Medicine | Tagged , , , , , , , , , | Leave a comment

Systems biology and “omics” technologies for better drug discovery and outcome studies in cancer treatment

The multiple platforms using the “omics” technologies and the integration of systems biology approaches including both experimental and computational methods would support both drug target discovery and clinical outcome studies, especially in cancer treatment. For instance, immunotherapies have become an … Continue reading

Posted in Immune, Systems Biology, Systems Medicine | Tagged , , , , , , , , , , , , , , , | Leave a comment