Tag Archives: SARS-CoV-2

Host Factors and Antiviral Targets

Host Factors and Antiviral Targets (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Host factors associated with SARS-CoV replication need to be investigated (de Wilde et al., 2015). These factors include the innate immune response and … Continue reading

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Saikosaponins and Coronaviruses

Saikosaponins (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Saikosaponins are oleanane derivatives including glucosides (Cheng et al., 2006). Saikosaponins are extracted from plants such as Bupleurum spp., Heteromorpha spp. and Scrophularia scorodonia. Saikosaponins have anti-inflammatory … Continue reading

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Antiviral Compounds and Human Coronavirus OC43

Antiviral Compounds and Human Coronavirus OC43 (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Stephania tetrandra and Menispermaceae contain the bis-benzylisoquinoline alkaloids tetrandrine (TET) (Kim et al., 2019). They also have fangchinoline (FAN) and cepharanthine (CEP). … Continue reading

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Herbal Extracts May Inhibit Coronavirus Replication

Herbal Extracts May Inhibit Coronavirus Replication (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Medicinal herbal extracts have been screened for their antiviral effects on coronavirus replication (Kim et al., 2008; Kim et al., 2010). The … Continue reading

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Sabadinine, Houttuynia Cordata, and Coronaviruses

Sabadinine and Houttuynia Cordata (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) The replication of CoVs relies on proteolytic processing (Toney et al., 2004). The major proteinase, 3C-like protease (3CLpro), may become a target for anti-SARS … Continue reading

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Glycyrrhizin, Cinnamomi Cortex, and Toona Sinensis Roem

Glycyrrhizin, Cinnamomi Cortex, and Toona Sinensis Roem (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Glycyrrhizin (GL) may suppress SARS-CoV replication (Hoever et al., 2005). The insertion of 2-acetamido-beta-d-glucopyranosylamine into the GL glycoside chain increased the … Continue reading

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The Antiviral Flavonoids for SARS-CoV and HCV

The Antiviral Flavonoids for SARS-CoV and HCV (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Aryl diketoacid (ADK) has antiviral effects that can be improved by adding an aromatic arylmethyl substituent (Park et al., 2012). A … Continue reading

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Emodin and the SARS Coronavirus

Emodin and the SARS Coronavirus (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) SARS-CoV spike (S) protein is a type I membrane-bound protein (Ho et al., 2007). It has an elemental role for the viral attachment … Continue reading

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Antiviral Herbal Compounds for SARS-CoV Ion Channels

Antiviral Herbal Compounds for SARS-CoV Ion Channels (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) The protein coded by the open-reading-frame 3a of SARS coronavirus may form a cation-selective channel (Schwarz et al., 2014). The channel … Continue reading

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Structural Analysis for Antiviral Compounds

Structural Analysis for Antiviral Compounds (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) The coronavirus main protease (M(pro)) is critical in viral gene expression (Xue et al., 2008). The viral replication through the proteolytic processing of … Continue reading

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About Coronaviruses (CoVs)

About Coronaviruses (CoVs) (From Potential Antiviral Agents for Coronavirus-es: Compounds, Herbal Products, and Drug Targets) Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available. The pandemic of the deadly coronavirus disease 2019 … Continue reading

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