Tag Archives: pathways

Cytokines, Depression, and Psychoneuroimmunology

Stress, Chronic Diseases, and Psychoneuroimmunology Stress, Depression, Inflammation, and Psychoneuroimmunology Cytokines such as interferon (IFN)-alpha may cause dopamine depletion and affect the pathways of monoamine metabolism. Their alterations may result in behavioral changes including depression, psychomotor slowing, and fatigue (Miller, … Continue reading

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Psychoneuroimmunology Database

The Database of Psychoneuroimmunology (DPNI) The Psychoneuroimmunology (PNI) Portal and Knowledge Base Potential Biomarkers for Anxiety The Database of Biomarkers: Depression Mind-Body Medicine About Meditation: The Portal and Knowledge Base The Nervous System Neuroinformatics The Database of Cytokines Chronobiology The … Continue reading

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Challenges in Biomarker Discovery

Although biomarkers have been considered more and more important, it is still very difficult to identify and validate effective and useful biomarkers. The obstacles in the biomarker identification include both technical and theoretical reasons. For example, methods for identifying pathology-type … Continue reading

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Alzheimer’s Disease and the Gene APOE (Apolipoprotein E)

The APOE gene has other symbols as “AD2”, “LPG”, “APO-E”, and “LDLCQ5”. It is located at 19q13.2. The APOE gene has important roles in cardiovascular diseases including myocardial infarction, ischemic stroke, and coronary heart disease (Kathiresan et al. 2008). The … Continue reading

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Network Interactions, Interactomes, and Drug Discovery

Because genes and proteins are functioning in complex networks and interactions, one molecule may influence other cellular elements in a broad range. These interactions can be studied in “interactomes”, a term referring to the protein-protein interaction networks (Chautard et al., … Continue reading

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Systems Biology and Neurodegenerative Diseases

Neurodegenerative diseases (NDs) are complex disorders that affect more than 40 million people globally (Wood et al., 2015). The multifaceted variations in the pathophysiology of the diseases make it difficult for effective therapy or prevention of the disease progression. More … Continue reading

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Systems Biology and Drug Screening

Conventional drug design mostly uses the ligand and structure-based approaches (Prathipati and Mizuguchi, 2015). With the advancement in functional genomics and the availability of high-throughput (HTP) data, information on interactive molecular networks can be used to analyze the efficacy and … Continue reading

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The integration of various “omics” technologies in systems biology for better diagnosis and treatment

With the advancements in the “omics” technologies and the information technology, systems biology has become an important approach for biomarker discovery. These technologies allow faster and cheaper analyses of gene expression, protein interactions, signaling pathways, and metabolic mechanisms. In this … Continue reading

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Individualized systems medicine (ISM): applications in the treatment of acute myeloid leukemia (AML)

Approaches in individualized systems medicine (ISM) or personalized systems medicine would be useful for achieving optimal therapies, especially in cancer treatment. Strategies in ISM have been suggested by Pemovska et al., by focusing on the establishment of molecular profiling (Pemovska … Continue reading

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