Tag Archives: pathway

Whole Grain Cereal, Obesity, and the PI3K/Akt Pathway

Whole grain cereal contains fibers, minerals, vitamins, and phytochemicals. Whole grain cereal has been found to inhibit body weight gain and non-alcoholic fatty liver (Lee et al., 2017). Whole grain cereal could decrease the atrophy-associated factors, fat pad mass, and … Continue reading

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The Interactions between Natural Killer Cells and Monocytes in Anti-Cancer Therapies

Human natural killer (NK) cells, monocytes, and dendritic cells are important components of the innate immune functions with instant protections against cancer cells and infections. Monocytes are large white blood cells (also called leukocytes). They can become macrophages and obtain … Continue reading

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Biomarkers for Inflammatory Breast Cancer

Inflammatory breast cancer (IBC) is an aggressive type of breast cancers (BC). Currently only a few specific genetic biomarkers or signatures have been identified for the disease. However, these genetic signatures are not very representative (Remo et al. 2015). More … Continue reading

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The Database of Biomarkers: Depression – Proteomic and Pathway Biomarkers

The Database of Biomarkers: Depression – Proteomic and Pathway Biomarkers •    Potential Biomarkers: The tryptophan-kynurenine pathway Detections: Increased indoleamine 2,3-dioxygenase activity Potential Applications: Diagnostic biomarkers References: Christmas DM, Potokar J, Davies SJ. A biological pathway linking inflammation and depression: activation … Continue reading

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The Database of Biomarkers: Proteomic and Pathway Biomarkers

Associated diseases/conditions: Depression   Potential Biomarkers: “Tumor Necrosis Factor (TNF) and its targets in the inflammatory cytokine pathway”   Detections: Protein expressions   Potential Applications: “Predictive biomarkers for treatment response (to the selective serotonin reuptake inhibitor (SSRI) antidepressant escitalopram)”   … Continue reading

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The Database of Biomarkers: Proteomic and Pathway Biomarkers – Cancers

Associated diseases/conditions: Non-small cell lung cancer (NSCLC)   Potential Biomarkers: Insulin-like growth factor (IGF) pathway   Detections: Protein expressions, serum levels   Potential Applications: Predictive biomarkers (tumor progression and patient outcomes)   References: Shersher DD, Vercillo MS, Fhied C, Basu … Continue reading

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Bioinformatics Databases and Tools for the Discovery of Proteomic and Pathway Biomarkers

BioLayout (http://www.biolayout.org/) Feature: “For the visualization and analysis of network graphs” Cytoscape (http://www.cytoscape.org/) Feature: “Network visualization” E-Cell (http://www.e-cell.org/) Feature: Computational models GelBank (http://gelbank.anl.gov/) Feature: “comparison of 2DE patterns in the context of proteome sequence queries” Gene Ontology (http://www.geneontology.org/) Feature: “Standardizing … Continue reading

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Systems biology strategies are useful for biomarker identification in traumatic brain injury (TBI)

The identification of biomarkers may have a significant influence on patient care. Biomarkers may be used for better diagnosis, disease profiling, research design, and drug target discovery. For instance, biomarkers have been considered to be critical in the management of … Continue reading

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