Tag Archives: networks

Psychoneuroimmunology Database

The Database of Psychoneuroimmunology (DPNI) The Psychoneuroimmunology (PNI) Portal and Knowledge Base Potential Biomarkers for Anxiety The Database of Biomarkers: Depression Mind-Body Medicine About Meditation: The Portal and Knowledge Base The Nervous System Neuroinformatics The Database of Cytokines Chronobiology The … Continue reading

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Translational Medicine and Drug Discovery

Recent development in translational medicine provides a connection between basic scientific studies and clinical practice. Such an initiative may support the patient-centered objectives in both research and clinical environments. It may also improve the drug discovery procedure by allowing for … Continue reading

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Challenges in Biomarker Discovery

Although biomarkers have been considered more and more important, it is still very difficult to identify and validate effective and useful biomarkers. The obstacles in the biomarker identification include both technical and theoretical reasons. For example, methods for identifying pathology-type … Continue reading

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Systems Biomarkers and Skin Diseases

With the development of systems biology, bioinformatics, ‘omics’ studies, more and more discoveries are made in the disorders including cardiovascular diseases and cancer. However, although sometimes ignored, other common illnesses with high incidences including skin diseases also need more assessments … Continue reading

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Network Interactions, Interactomes, and Drug Discovery

Because genes and proteins are functioning in complex networks and interactions, one molecule may influence other cellular elements in a broad range. These interactions can be studied in “interactomes”, a term referring to the protein-protein interaction networks (Chautard et al., … Continue reading

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Systems Biology and Neurodegenerative Diseases

Neurodegenerative diseases (NDs) are complex disorders that affect more than 40 million people globally (Wood et al., 2015). The multifaceted variations in the pathophysiology of the diseases make it difficult for effective therapy or prevention of the disease progression. More … Continue reading

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Systems Biology and Drug Screening

Conventional drug design mostly uses the ligand and structure-based approaches (Prathipati and Mizuguchi, 2015). With the advancement in functional genomics and the availability of high-throughput (HTP) data, information on interactive molecular networks can be used to analyze the efficacy and … Continue reading

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Systems Biology, miRNAs, and Alzheimer’s Disease

Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial involving genomics, metabolomics, epigenomics, transcriptomics, interactomics, as well as environmental components. Systemic understanding of these complex diseases may start with the alterations in the cellular networks. Investigation in integrative systems biology … Continue reading

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Systems medicine, P4 medicine, and an integrative “Human Model”

Conventional practice in Western medicine focuses on doctors’ “reactive” interventions in response to the occurrence of diseases. With the advancement of genomics, proteomics, and various high efficient “omics” technologies, the multidimensional networks of the human body can be investigated for … Continue reading

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