Tag Archives: network

Genetic Networks and Biomarkers

The post-genomic research based on large cohorts of preclinical studies have produced multi-dimensional genetic and transcriptomic data sets. The revelation of the molecular pathways and cellular networks associated with various diseases may promote the systems biology studies of the onset … Continue reading

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Systems Biology and Subnetworks in Breast Cancer

As a complex disease with heterogeneous factors involved, breast cancer have various subtypes with distinct therapeutic response patterns and outcomes (Yersal and Barutca, 2014). Conventional classification systems of breast cancer have limitations in describing such features. In order to achieve … Continue reading

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Nutritional Systems Biology and Type 2 Diabetes

Systems biology studies include the investigations in various “omics” areas, such as genomics, transcriptomics, proteomics, metabolomics, epigenomics, as well as microbiomics. Combining both computational and experimental biology, systems biology aims at prediction of the dynamical processes and the description of … Continue reading

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Bioinformatics Databases and Tools for the Discovery of Proteomic and Pathway Biomarkers

BioLayout (http://www.biolayout.org/) Feature: “For the visualization and analysis of network graphs” Cytoscape (http://www.cytoscape.org/) Feature: “Network visualization” E-Cell (http://www.e-cell.org/) Feature: Computational models GelBank (http://gelbank.anl.gov/) Feature: “comparison of 2DE patterns in the context of proteome sequence queries” Gene Ontology (http://www.geneontology.org/) Feature: “Standardizing … Continue reading

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Review of Systems Biology Approaches: Detecting Signaling Pathways in Neurons

Temporal dynamics and spatial features are important factors in cell responses including synaptic plasticity. The complex network and interactions among neuronal signaling pathways result in emergent dynamical behaviors associated with synaptic plasticity. Signaling pathways can be activated by transmembrane receptors … Continue reading

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Neuroinformatics Databases about the Brain: Different Species

Neuroinformatics Databases about the Brain: Different Species   Species Source Name Purposes/Features/Methods Contents Applications URL References Mouse 3D digital atlas database of the mouse brain Lower spatial resolution images were utilized to enhance time efficiency for morphological phenotyping The in … Continue reading

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