Systems Biology Technologies and Cancer Immunotherapy

Decades of scientific studies have demonstrated the essential role of the immune system in cancer pathology and clinical treatment. The immune system may regulate the growth of tumors via the complex interactions among molecules, genes, cells, and organs. The elucidation of such mechanisms is critical for immunotherapy, a novel treatment method that has been found promising.

Recently multiple applications of immunotherapies have received US FDA approvals (Guhathakurta et al. 2013). Immunotherapies are becoming a more and more important therapeutic strategy for cancers.

The approaches of systems biology and “omics” technologies including the high-throughput (HTP) profiling may help understand the complexity in the processes of tumor immunosurveillance and different types of immune phenotypes (Guhathakurta et al. 2013). Such mechanisms may be important for the further advancements in immunotherapies.


Guhathakurta D, Sheikh NA, Meagher TC, Letarte S, Trager JB. Applications of systems biology in cancer immunotherapy: from target discovery to biomarkers of clinical outcome. Expert Rev Clin Pharmacol. 2013 Jul;6(4):387-401. doi: 10.1586/17512433.2013.811814.

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