Systems Biology and Neurodegenerative Diseases

Neurodegenerative diseases (NDs) are complex disorders that affect more than 40 million people globally (Wood et al., 2015). The multifaceted variations in the pathophysiology of the diseases make it difficult for effective therapy or prevention of the disease progression. More comprehensive approaches would be necessary to solve the complex problems.

Genomic studies have identified genetic loci and variants that are related to neurodevelopmental and neurodegenerative disorders (Parikshak et al., 2015). With the development in transcriptomics and systems biology based on high-throughput (HTP) techniques, such relationships can be understood in a hierarchical context from molecular interactions, cellular pathways, to neural circuits and cognition.

The integration of the multi-dimensional analyses including microarray and mass spectrometry would enable the systematic investigation of the mechanisms underlying the onset and progression of NDs (Wood et al., 2015).

References:

Parikshak NN, Gandal MJ, Geschwind DH. Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders. Nat Rev Genet. 2015 Aug;16(8):441-58. doi: 10.1038/nrg3934.

Wood LB, Winslow AR, Strasser SD. Systems biology of neurodegenerative diseases. Integr Biol (Camb). 2015 Jul 6;7(7):758-75. doi: 10.1039/c5ib00031a.

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