Systems Biology and Companion Diagnostics

The development in high-throughput (HTP) technologies and computational biology may help define the next generation of biomarkers. By providing an integrative viewpoint, systems biology may improve the understanding of the complexity in biological systems.

The assemblage of interacting molecular elements and multiple interconnecting relationships may contribute to the development of companion diagnostics and novel therapeutics (Caberlotto and Lauria 2015). The approaches based on systems biology would enable the development of novel strategies for the discovery of signatures or biomarkers for both disease progression and drug responses.

The advances of the systems biology perspectives would improve the current diagnosis and drug discovery processes. Applying systems biology approaches in companion diagnostics may be very helpful for these purposes.

Companion diagnostic uses medical devices to obtain information about the safety and effectiveness of drugs or therapeutic products. Such analyses may assist the decision making of patient-specific treatments for the better selections of drugs and dosages.


Caberlotto L, Lauria M. Systems biology meets -omic technologies: novel approaches to biomarker discovery and companion diagnostic development. Expert Rev Mol Diagn. 2015 Feb;15(2):255-65. doi: 10.1586/14737159.2015.975214.

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