Stress, Depression, and Serum Enzyme Activities

Depression has been associated with the activities of many enzymes, including the serum creatine kinase (CK) and lactate dehydrogenase (LDH) (Kato et al., 2014). Such changes may occur even in healthy people under stress with certain depressive symptoms.

In a recent study of 93 healthy female nursing home workers, the levels of total CK, LDH activities, as well as serum CK isozyme muscle-type M chain (CK-MM) were measured (Kato et al., 2014). The levels of the enzymes were related to the depressive symptoms of the nurses with distress.

Such studies have shown that activities of the enzymes including serum CK, LDH, and serum CK-MM levels can be useful indicators of work associated-distress and depressive symptoms (Kato et al., 2014). Further studies are still needed to elucidate the detailed mechanisms of the associations among stress, depression, and enzymes including CK and LDH. It would be also interesting to find out how these connections and changes influence other physiological activities and the potential pathological results.


Kato A, Sakakibara H, Tsuboi H, Tatsumi A, Akimoto M, Shimoi K, Ishii T, Kaneko H, Nakayama T, Ohashi N. Depressive symptoms of female nursing staff working in stressful environments and their association with serum creatine kinase and lactate dehydrogenase – a preliminary study. Biopsychosoc Med. 2014 Sep 9;8:21. doi: 10.1186/1751-0759-8-21.

This entry was posted in Psychoneuroimmunology and tagged , , , , , , , . Bookmark the permalink.

Leave a Reply