Potential Antiviral Compounds for Coronaviruses: Tests and Screenings

Potential Antiviral Compounds for Coronaviruses: Tests and Screenings

(From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets)

  • Some agents inhibiting coronaviral replication have been investigated (Golda and Pyrc, 2008).
  • The potential antiviral agents include (Golda and Pyrc, 2008):
    • Carbohydrate-binding agents;
    • Neutralizing antibodies;
    • Drugs targeting the coronaviral envelope protein.
  • Real-time PCR has been used for testing antivirals against Lassa virus, SARS coronavirus, and Ebola virus (Günther et al., 2004).
  • A small-scale screening found a class of imidazole nucleoside/nucleotide analogues with antiviral activities against Lassa virus.
  • The analogues had dinitrile or diester groups at the imidazole 4,5-positions (Günther et al., 2004).
  • Many of these had an acyclic sugar or sugar phosphonate moiety at the imidazole 1-position.
  • The compounds also suppressed the replications of SARS and Ebola viruses (Günther et al., 2004).
  • These compounds may be useful for the development of broad-spectrum drugs against viruses.

References:

Golda, A., & Pyrc, K. (2008). Recent antiviral strategies against human coronavirus-related respiratory illnesses. Current Opinion in Pulmonary Medicine, 14(3), 248–253. https://doi.org/10.1097/MCP.0b013e3282f7646f

Günther, S., Asper, M., Röser, C., Luna, L. K. S., Drosten, C., Becker-Ziaja, B., Borowski, P., Chen, H.-M., & Hosmane, R. S. (2004). Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus and Ebola virus in vitro. Antiviral Research, 63(3), 209–215. https://doi.org/10.1016/j.antiviral.2004.05.001

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