Obesity, Emotional Conditions, Eating Behaviors, and Inflammation

Stress, Chronic Diseases, and Psychoneuroimmunology

Stress, Depression, Inflammation, and Psychoneuroimmunology

Obesity has been associated with chronic low-degree inflammation that can result in stress and behavioral problems. A study investigated the correlations among adiposity, low-grade inflammation, eating behaviors, and emotional conditions among obese women going through gastric surgery (Capuron et al., 2011).

The study examined 101 women with severe or morbid obesity before and one year after the gastric surgery (Capuron et al., 2011). The roles of surgery-caused weight loss in the correlations were also assessed.

The study showed that the levels of serum inflammatory biomarkers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP) were related to the depression and anxiety aspects of neuroticism (Capuron et al., 2011). Elevated levels of inflammation predicted increased levels of anxiety and depression. Lower levels of inflammatory biomarkers, especially lower levels of hsCRP were related to lower levels of anxiety and moderate eating behaviors.

The study demonstrated that obesity is tightly related to chronic low-grade inflammation. The body mass index (BMI) has been associated with inflammatory biomarkers and adipokines (Capuron et al., 2011). On the other hand, gastric surgery resulted in weight loss and lower levels of inflammation.

The study confirmed the close correlations among adiposity, inflammation and affectivity in obesity (Capuron et al., 2011). Surgery-caused weight loss has been related to lower levels of inflammation and adipokines including leptin and adiponectin.

In addition, weight loss has been associated with better emotional conditions and eating behaviors (Capuron et al., 2011). The inflammatory conditions may be the critical factors connecting emotional distress and psychological conditions in obesity.


Capuron L, Poitou C, Machaux-Tholliez D, Frochot V, Bouillot JL, Basdevant A, Layé S, Clément K. Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation. Psychol Med. 2011 Jul;41(7):1517-28. doi: 10.1017/S0033291710001984.

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