Neuroinformatics Databases about the Brain Structures

Neuroinformatics Databases about the Brain Structures

 

The Internet Brain Volume Database (IBVD) (Kennedy et al., 2012)

  • The URL: http://www.nitrc.org/projects/ibvd
  • The background
    • Publications available about
      • Neuroanatomic volumetric observations
      • Large data sets of volumetric measurements with variables of
        • Specific species
        • Structures
        • Subject features
          • Gender
          • Age
          • Pathology
          • The Internet Brain Volume Database (IBVD)
            • About neuroanatomic volumetric observations from available publications
            • For integrating, sharing, and accessing data
            • Includes data about various species
            • Includes data about different diseases
            • To support quality assurance evaluations
            • To support meta-analysis

 

 

Brainpeps: a database about the blood-brain barrier peptide (Van Dorpe et al., 2012)

  • The URL: http://brainpeps.ugent.be/
  • The background
    • Peptides can cross the blood-brain barrier (BBB) via different mechanisms
    • These peptides can be useful for diagnostic and therapeutic purposes
    • The BBB transport data have not been previously organized or collected
    • Brainpeps: a comprehensive BBB peptide database
      • To gather the BBB data from the literature
      • Contents: BBB transport information
      • Applications
        • To prioritize peptide selections for analyzing various BBB responses
        • For quantitative analyses of peptide structure-function (BBB behavior) associations
        • To classify the different methods in analyzing the BBB behaviors and responses to various compounds
        • To analyze the associations between the different BBB transport methods

 

 

The OASIS Brain Database: An application (Ardekani et al., 2012)

  • The URL: http://www.oasis-brains.org/
  • The background
    • Studies have shown that  the midsagittal corpus callosum cross-sectional area (CCA) in females may be larger than those in males in average
    • Such observation may be caused by spurious differences in the CCA-to-brain-size ratio
    • The study
      • Data source:
        • The OASIS (Open Access Series of Imaging Studies)
  • The CCAs were analyzed on magnetic resonance imaging (MRI) scans
  • The method
    • Multiple regression analysis
  • The null hypothesis
    • The average CCA is the same between genders
  • An additional study was done on a subset of young adults
  • The results
    • The null hypothesis was found false in both analyses
    • The average CCA was found larger in females, especially in the young adults
    • The results were reached based on the correction for the confounding factor of brain sizes

 

 

References

 

Ardekani, B. A., Figarsky, K., & Sidtis, J. J. (2012). Sexual Dimorphism in the Human Corpus Callosum: An MRI Study Using the OASIS Brain Database. Cerebral cortex (New York, N.Y.: 1991). doi:10.1093/cercor/bhs253

 

Kennedy, D. N., Hodge, S. M., Gao, Y., Frazier, J. A., & Haselgrove, C. (2012). The internet brain volume database: a public resource for storage and retrieval of volumetric data. Neuroinformatics, 10(2), 129–140. doi:10.1007/s12021-011-9130-1

 

Van Dorpe, S., Bronselaer, A., Nielandt, J., Stalmans, S., Wynendaele, E., Audenaert, K., … De Spiegeleer, B. (2012). Brainpeps: the blood-brain barrier peptide database. Brain structure & function, 217(3), 687–718. doi:10.1007/s00429-011-0375-0

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