Mind-Body Medicine for Cognitive Impairment in Multiple Sclerosis

Patients of multiple sclerosis (MS) often suffer from cognitive impairment, which is incapacitating and affects the quality of life. Personalized preventive and treatment methods are needed to address this serious problem as different MS patients may have different neuropsychological profiles.

Recent studies have emphasized on the models including cognitive reserve and brain reserve (Crescentini et al., 2014) that describe the mind’s resilience to brain damage. The inter-individual divergence in cognitive impairment and pathology among MS patients has been noticed. Such understanding would be helpful for the development of individualized clinical therapeutic strategies for cognitive dysfunction among MS patients.

In addition to pharmaceutical treatment, integrative methods from mind-body medicine including the techniques of mindfulness meditation have been proposed to potentiate cognitive and brain reserve in MS patients (Crescentini et al., 2014). Such methods may help enrich mental activities and cultivate cognitive reserve.

To have a better understanding of such mind-body methods and their effects on cognitive degradation in multiple sclerosis, both clinical trials and laboratory experimental examinations are needed. Studies on the scientific mechanisms would also be helpful.


Crescentini C, Urgesi C, Fabbro F, Eleopra R. Cognitive and brain reserve for mind-body therapeutic approaches in multiple sclerosis: A review. Restor Neurol Neurosci. 2014 Jan 1;32(5):575-95. doi: 10.3233/RNN-130364.

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