Lipidomics, Circadian Rhythms, and Chronobiology

Lipids are essential for biological mechanisms, from serving as signaling molecules to maintaining cellular processes. They are fundamental elements that compose cellular membranes. They are also the basis of energy storage. In addition to all of these functions, lipids are closely associated with circadian rhythms that control the regular metabolism and physiological processes on a daily basis (Adamovich et al., 2014).

The disturbance of the circadian oscillation has been related to disrupted lipid homeostasis and many health problems including metabolic syndromes, fatty liver, obesity (Adamovich et al., 2014), as well as diabetes. On the other hand, lipids have key roles in the central clock circuitry and circadian regulation processes, and are critical for their normal performances.

The crosstalk between circadian oscillation and lipid homeostasis requires more studies in lipidomics as well as its roles in chronobiology. Specifically, more investigations are needed to find out how lipids influence the circadian clock’s performance at different levels, as well as the associations between lipid homeostasis and circadian rhythmicity. Such studies would also contribute to a better understanding of relevant diseases such as obesity, diabetes, and heart diseases.

Reference:

Adamovich Y, Aviram R, Asher G. The emerging roles of lipids in circadian control. Biochim Biophys Acta. 2014 Dec 4. pii: S1388-1981(14)00252-2. doi: 10.1016/j.bbalip.2014.11.013.

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