Inflammation and Diseases

  • Inflammation is an immune response of the body to protect from irritants, stimuli, or external materials that may be detrimental.
  • Inflammatory signs:
    • Redness
    • Swelling
    • Heat
    • Pain
  • Immune surveillance:
    • The immune system can monitor, find, and remove the useless or damaging materials from inside or outside, e.g., cancer cells.
  • Inflammation is critical in many diseases:
    • acute diseases, e.g.,
      • Flu
      • Meningitis
      • Pneumonia,
    • Allergies, e.g.,
      • Asthma
      • Ocular inflammatory disorders
      • Skin disorders
    • Age-associated diseases, e.g.,
      • Neurodegenerative diseases
        • Alzheimer’s disease
        • Parkinson’s disease
      • Autoimmune diseases
        • Rheumatoid arthritis
        • Multiple sclerosis
      • Hypertension
      • Diabetes
      • Cardiovascular diseases
      • Colitis
      • Gastritis
      • Nephritis
      • Pancreatitis
      • Thyroiditis
      • Fibromyalgia
      • Lupus
      • Psoriasis
      • Cancers, e.g.,
        • Lung
        • colon/rectal
        • breast
        • cervical
        • prostate
        • bladder
        • liver
        • gall bladder
        • ovarian
        • pancreas
        • brain

References:

Burnet, M. Cancer; a biologic approach. I. The processes of control. Br. Med. J. 1957, 1, 779–786.

Ehrlich, P. Uber den jetzigen Stand der Karzinomforschung. Ned. Tijdschr. Geneeskd. 1909, 5, 273–290.

Goronzy, J.J.; Wevand, C.M. T cell development and receptor diversity during aging. Curr. Opin. Immunol. 2005, 17, 468–475.

Khatami, M. Inflammation, Aging and Cancer: Friend or For? In Inflammation, Chronic Diseases and Cancer. Cell and Molecular Biology, Immunology and Clinical Bases; Khatami, M., Ed.; InTech: Rijeka, Croatia, 2012; pp. 3–30.

Khatami, M. Unresolved inflammation and cancer: Loss of natural immune surveillance as the correct ―target‖ for therapy! Seeing the ―Elephant‖ in the light of logic. Cell Biochem. Biophys. 2012, 62, 501–509.

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