Glycyrrhizin, Cinnamomi Cortex, and Toona Sinensis Roem

Glycyrrhizin, Cinnamomi Cortex, and Toona Sinensis Roem

(From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets)

  • Glycyrrhizin (GL) may suppress SARS-CoV replication (Hoever et al., 2005).
  • The insertion of 2-acetamido-beta-d-glucopyranosylamine into the GL glycoside chain increased the antiviral effects to 10-fold higher.
  • Amides and conjugates of GL with two amino acid residues and a free 30-COOH function increased the effects up to 70-fold higher.
  • However, they caused higher cytotoxicity with lower selectivity index (Hoever et al., 2005).
  • In addition, the butanol fraction of Cinnamomi Cortex (CC/Fr.2) may suppress SARS-CoV (Zhuang et al., 2009).
  • It may also inhibit HIV/SARS-CoV S pseudovirus infections.
  • The compounds from CC such as procyanidin A2 and procyanidin B1 may have moderate antiviral effects (Zhuang et al., 2009).
  • CC/Fr.2 could block the clathrin-dependent endocytosis pathway and suppress the internalization of transferrin receptor.
  • CC/Fr.2 may have the antiviral activities for SARS-CoV by blocking endocytosis (Zhuang et al., 2009).
  • Moreover, TSL-1, the extract from Toona sinensis Roem (Cedrela sinensis; TSR), may also inhibit SARS-CoV (Chen et al., 2008).

References:

Chen, C.-J., Michaelis, M., Hsu, H.-K., Tsai, C.-C., Yang, K. D., Wu, Y.-C., Cinatl, J., & Doerr, H. W. (2008). Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication. Journal of Ethnopharmacology, 120(1), 108–111.

Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, G. A., Doerr, H. W., & Cinatl, J. (2005). Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus. Journal of Medicinal Chemistry, 48(4), 1256–1259.

Zhuang, M., Jiang, H., Suzuki, Y., Li, X., Xiao, P., Tanaka, T., Ling, H., Yang, B., Saitoh, H., Zhang, L., Qin, C., Sugamura, K., & Hattori, T. (2009). Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Research, 82(1), 73–81.

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