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Category Archives: Systems Medicine
The Spike Protein, ACE2, and Coronaviruses
The Spike Protein, ACE2, and Coronaviruses (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) It is important to understand the SARS-CoV genome, evolution and lifecycle. The spike (S) protein of the SARS-CoV is essential in viral … Continue reading
Posted in Infectious Diseases
Tagged ACE2, antiviral, Coronaviruses, COVID-19, drug targets, SARS, SARS-CoV-2, spike protein, vaccines, viruses
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Host Factors and Antiviral Targets
Host Factors and Antiviral Targets (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Host factors associated with SARS-CoV replication need to be investigated (de Wilde et al., 2015). These factors include the innate immune response and … Continue reading
Posted in Infectious Diseases
Tagged antiviral, Coronavirus, COVID-19, drug discovery, drug targets, host, SARS, SARS-CoV-2
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Saikosaponins and Coronaviruses
Saikosaponins (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Saikosaponins are oleanane derivatives including glucosides (Cheng et al., 2006). Saikosaponins are extracted from plants such as Bupleurum spp., Heteromorpha spp. and Scrophularia scorodonia. Saikosaponins have anti-inflammatory … Continue reading
Posted in Herbal Medicine, Infectious Diseases
Tagged antiviral, Coronavirus, herbal, herbs, immune, inflammation, SARS, SARS-CoV-2, viral replication, viruses
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Antiviral Compounds and Human Coronavirus OC43
Antiviral Compounds and Human Coronavirus OC43 (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Stephania tetrandra and Menispermaceae contain the bis-benzylisoquinoline alkaloids tetrandrine (TET) (Kim et al., 2019). They also have fangchinoline (FAN) and cepharanthine (CEP). … Continue reading
Posted in Herbal Medicine, Infectious Diseases
Tagged antiviral, compounds, Coronavirus, herbal, herbs, infections, lung, SARS, SARS-CoV-2, viruses
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Herbal Extracts May Inhibit Coronavirus Replication
Herbal Extracts May Inhibit Coronavirus Replication (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Medicinal herbal extracts have been screened for their antiviral effects on coronavirus replication (Kim et al., 2008; Kim et al., 2010). The … Continue reading
Posted in Herbal Medicine, Infectious Diseases
Tagged antiviral, Coronavirus, COVID-19, hepatitis virus, herbal, herbs, SARS, SARS-CoV-2, viral replication, viruses
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Antiviral Flavonoids from Houttuynia Cordata
Antiviral Flavonoids from Houttuynia Cordata (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) The ethyl acetate (EA) fraction of Houttuynia cordata (H. cordata) Thunb. (Saururaceae) may have antiviral effects. It may be used against coronaviruses and … Continue reading
Posted in Herbal Medicine, Infectious Diseases
Tagged antiviral, Coronavirus, COVID-19, flavonoids, hepatitis virus, herbal, herbs, infections, SARS, viruses
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Sabadinine, Houttuynia Cordata, and Coronaviruses
Sabadinine and Houttuynia Cordata (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) The replication of CoVs relies on proteolytic processing (Toney et al., 2004). The major proteinase, 3C-like protease (3CLpro), may become a target for anti-SARS … Continue reading
Posted in Herbal Medicine, Infectious Diseases
Tagged antiviral, Coronavirus, herbal, herbs, Houttuynia Cordata, Sabadinine, SARS, SARS-CoV-2, T cells, viruses
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Glycyrrhizin, Cinnamomi Cortex, and Toona Sinensis Roem
Glycyrrhizin, Cinnamomi Cortex, and Toona Sinensis Roem (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Glycyrrhizin (GL) may suppress SARS-CoV replication (Hoever et al., 2005). The insertion of 2-acetamido-beta-d-glucopyranosylamine into the GL glycoside chain increased the … Continue reading
Posted in Herbal Medicine, Infectious Diseases
Tagged antiviral, Cinnamomi Cortex, Coronavirus, Glycyrrhizin, herbal, herbs, infections, SARS-CoV-2, Toona Sinensis Roem, viruses
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The Antiviral Flavonoids for SARS-CoV and HCV
The Antiviral Flavonoids for SARS-CoV and HCV (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Aryl diketoacid (ADK) has antiviral effects that can be improved by adding an aromatic arylmethyl substituent (Park et al., 2012). A … Continue reading
Posted in Herbal Medicine, Infectious Diseases
Tagged antiviral, Coronavirus, flavonoids, HCV, hepatitis C, herbal, quercetin, SARS-CoV-2, virus
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Antiviral Herbal Compounds for SARS-CoV Ion Channels
Antiviral Herbal Compounds for SARS-CoV Ion Channels (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) The protein coded by the open-reading-frame 3a of SARS coronavirus may form a cation-selective channel (Schwarz et al., 2014). The channel … Continue reading
The Antiviral Compound for MERS-CoV
The Antiviral Compound for MERS-CoV (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) A type of nucleoside analogues may be similar to the natural nucleosides that can block viral replication (Agostini et al., 2019). Potent antiviral … Continue reading
Posted in Infectious Diseases
Tagged antiviral, Coronavirus, drug discovery, infections, infectious diseases, inhibitor, MERS, MHV, viruses
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Structural Analysis for Antiviral Compounds
Structural Analysis for Antiviral Compounds (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) The coronavirus main protease (M(pro)) is critical in viral gene expression (Xue et al., 2008). The viral replication through the proteolytic processing of … Continue reading
Potential Antiviral Compounds for Coronaviruses: Tests and Screenings
Potential Antiviral Compounds for Coronaviruses: Tests and Screenings (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Some agents inhibiting coronaviral replication have been investigated (Golda and Pyrc, 2008). The potential antiviral agents include (Golda and Pyrc, … Continue reading
Posted in Infectious Diseases
Tagged agents, antibodies, antiviral, compounds, Coronavirus, Coronaviruses, drug screening, Ebola, imidazole, SARS, virus, viruses
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Antiviral Antibodies, Immunity, and Coronaviruses
Antiviral Antibodies and Coronaviruses (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Mutations in virus-derived CD8 T-cell epitopes may abolish cytotoxic T-lymphocyte (CTL) recognition (Butler et al., 2007). The mutations may block virus clearance in coronavirus-infected … Continue reading
Posted in Infectious Diseases
Tagged antibodies, antiviral, Coronavirus, Coronaviruses, cytokines, immune, immunity, T cells, vaccination, vaccines, viruses
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Potential Antiviral Agents for SARS and Various Coronaviruses
Indomethacin for Various Coronaviruses (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Cyclopentenone cyclooxygenase (COX) metabolites have been found to be useful targets against RNA viruses (Amici et al., 2006). The COX inhibitor indomethacin (INDO) may … Continue reading
Posted in Infectious Diseases
Tagged antiviral, Broad-spectrum, Coronavirus, Coronaviruses, HCV, hepatitis C, hepatitis virus, Indomethacin, infections, inflammatory, P-PMOs, SARS, virus
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Remdesivir and Chloroquine as Potential Broad-Spectrum Antiviral Drugs
Remdesivir As A Potential Broad-Spectrum Antiviral Drug (From Potential Antiviral Agents for Coronavirus-es: Compounds, Herbal Products, and Drug Targets) The nucleoside analogue GS-5734 (remdesivir) has been found to inhibit human and zoonotic CoVs (Agostini et al., 2018). GS-5734 may inhibit … Continue reading
Broad-Spectrum Antiviral Drugs for Coronaviruses
Broad-Spectrum Antiviral Drugs for Coronaviruses (From Potential Antiviral Agents for Coronavirus-es: Compounds, Herbal Products, and Drug Targets) Broad-spectrum antiviral drugs may lower the vulnerability of public health systems to the coronavirus pandemic. Broad-spectrum antiviral drugs are needed to Combat the … Continue reading
Posted in Immune, Infectious Diseases, Systems Medicine
Tagged antiviral, Broad-spectrum, Coronavirus, Coronaviruses, covid, COVID-19, drug discovery, drugs, infections, MERS, pan-coronavirus, pandemic, SARS
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About Coronaviruses (CoVs)
About Coronaviruses (CoVs) (From Potential Antiviral Agents for Coronavirus-es: Compounds, Herbal Products, and Drug Targets) Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available. The pandemic of the deadly coronavirus disease 2019 … Continue reading
Studies about Antiviral Drugs for Coronaviruses
The Antiviral Remdesivir and the Coronavirus SARS-CoV Agostini, M. L., Andres, E. L., Sims, A. C., Graham, R. L., Sheahan, T. P., Lu, X., Smith, E. C., Case, J. B., Feng, J. Y., Jordan, R., Ray, A. S., Cihlar, T., … Continue reading
Posted in Immune, Infectious Diseases
Tagged antiviral, Coronavirus, Coronaviruses, covid, COVID-19, drugs, pandemic, SARS, virus, viruses
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Resources for Studying the 2019-nCoV Coronavirus (COVID-19): Databases and Tools
Resources for Studying the 2019-nCoV Coronavirus (COVID-19): Databases and Tools “human coronaviruses such as …endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days…” From Persistence of coronaviruses on inanimate surfaces … Continue reading
Posted in Bioinformatics, Immune, Infectious Diseases, Mind-Body
Tagged 2019-nCoV, bioinformatics, Coronavirus, COVID-19, databases, diagnosis, Epidemiology, evolution, genes, Sequences, transmission, virus, Wuhan
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Biomarkers Database: Obesity in Different Populations
Park, B.-Y., Hong, J., & Park, H. (2017). Neuroimaging biomarkers to associate obesity and negative emotions. Scientific Reports, 7(1), 7664. https://doi.org/10.1038/s41598-017-08272-8 Pecht, T., Gutman-Tirosh, A., Bashan, N., & Rudich, A. (2014). Peripheral blood leucocyte subclasses as potential biomarkers of adipose … Continue reading
Posted in Bioinformatics, Biomarkers, Obesity
Tagged biomarker, biomarkers, Database, databases, obese, obesity, personalized medicine, phenotypes, population
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Biomarkers Database: Obesity, Cognition, and Inflammation
Garcia-Mazcorro, J. F., Mills, D. A., Murphy, K., & Noratto, G. (2018). Effect of barley supplementation on the fecal microbiota, caecal biochemistry, and key biomarkers of obesity and inflammation in obese db/db mice. European Journal of Nutrition, 57(7), 2513–2528. https://doi.org/10.1007/s00394-017-1523-y … Continue reading
Posted in Bioinformatics, Biomarkers, Obesity
Tagged biomarker, biomarkers, Cognition, Database, databases, inflammation, obese, obesity
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