Author Archives: Pharm Tao

Structural Analysis for Antiviral Compounds

Structural Analysis for Antiviral Compounds (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) The coronavirus main protease (M(pro)) is critical in viral gene expression (Xue et al., 2008). The viral replication through the proteolytic processing of … Continue reading

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Potential Antiviral Compounds for Coronaviruses: Tests and Screenings

Potential Antiviral Compounds for Coronaviruses: Tests and Screenings (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Some agents inhibiting coronaviral replication have been investigated (Golda and Pyrc, 2008). The potential antiviral agents include (Golda and Pyrc, … Continue reading

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Antiviral Antibodies, Immunity, and Coronaviruses

Antiviral Antibodies and Coronaviruses (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Mutations in virus-derived CD8 T-cell epitopes may abolish cytotoxic T-lymphocyte (CTL) recognition (Butler et al., 2007). The mutations may block virus clearance in coronavirus-infected … Continue reading

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Potential Antiviral Agents for SARS and Various Coronaviruses

Indomethacin for Various Coronaviruses (From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets) Cyclopentenone cyclooxygenase (COX) metabolites have been found to be useful targets against RNA viruses (Amici et al., 2006). The COX inhibitor indomethacin (INDO) may … Continue reading

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Remdesivir and Chloroquine as Potential Broad-Spectrum Antiviral Drugs

Remdesivir As A Potential Broad-Spectrum Antiviral Drug (From Potential Antiviral Agents for Coronavirus-es: Compounds, Herbal Products, and Drug Targets) The nucleoside analogue GS-5734 (remdesivir) has been found to inhibit human and zoonotic CoVs (Agostini et al., 2018). GS-5734 may inhibit … Continue reading

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Broad-Spectrum Antiviral Drugs for Coronaviruses

Broad-Spectrum Antiviral Drugs for Coronaviruses (From Potential Antiviral Agents for Coronavirus-es: Compounds, Herbal Products, and Drug Targets) Broad-spectrum antiviral drugs may lower the vulnerability of public health systems to the coronavirus pandemic. Broad-spectrum antiviral drugs are needed to Combat the … Continue reading

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About Coronaviruses (CoVs)

About Coronaviruses (CoVs) (From Potential Antiviral Agents for Coronavirus-es: Compounds, Herbal Products, and Drug Targets) Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available. The pandemic of the deadly coronavirus disease 2019 … Continue reading

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Studies about Antiviral Drugs for Coronaviruses

The Antiviral Remdesivir and the Coronavirus SARS-CoV Agostini, M. L., Andres, E. L., Sims, A. C., Graham, R. L., Sheahan, T. P., Lu, X., Smith, E. C., Case, J. B., Feng, J. Y., Jordan, R., Ray, A. S., Cihlar, T., … Continue reading

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Resources for Studying the 2019-nCoV Coronavirus (COVID-19): Databases and Tools

Resources for Studying the 2019-nCoV Coronavirus (COVID-19): Databases and Tools “human coronaviruses such as …endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days…” From Persistence of coronaviruses on inanimate surfaces … Continue reading

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Metabolomics of Obesity: Gut Microbiota

Recent Development in Metabolomics of Obesity: Gut Microbiota and Metabolic Syndrome Abu Bakar, M. H., Sarmidi, M. R., Cheng, K.-K., Ali Khan, A., Suan, C. L., Zaman Huri, H., & Yaakob, H. (2015). Metabolomics – the complementary field in systems … Continue reading

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Biomarkers Database: Obesity in Different Populations

Park, B.-Y., Hong, J., & Park, H. (2017). Neuroimaging biomarkers to associate obesity and negative emotions. Scientific Reports, 7(1), 7664. https://doi.org/10.1038/s41598-017-08272-8 Pecht, T., Gutman-Tirosh, A., Bashan, N., & Rudich, A. (2014). Peripheral blood leucocyte subclasses as potential biomarkers of adipose … Continue reading

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Biomarkers Database: Obesity, Cognition, and Inflammation

Garcia-Mazcorro, J. F., Mills, D. A., Murphy, K., & Noratto, G. (2018). Effect of barley supplementation on the fecal microbiota, caecal biochemistry, and key biomarkers of obesity and inflammation in obese db/db mice. European Journal of Nutrition, 57(7), 2513–2528. https://doi.org/10.1007/s00394-017-1523-y … Continue reading

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Biomarkers Database: Obesity, Metabolic Disorders, and Cardiovascular Risks

Aleksandrova, K., Mozaffarian, D., & Pischon, T. (2018). Addressing the Perfect Storm: Biomarkers in Obesity and Pathophysiology of Cardiometabolic Risk. Clinical Chemistry, 64(1), 142–153. https://doi.org/10.1373/clinchem.2017.275172 Bagheri, M., Djazayery, A., Qi, L., Yekaninejad, M. S., Chamari, M., Naderi, M., … Farzadfar, … Continue reading

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Potential Biomarkers of Obesity

For obesity with cardiovascular diseases: Peterson, S. J., Shapiro, J. I., Thompson, E., Singh, S., Liu, L., Weingarten, J. A., … Abraham, N. G. (2019). Oxidized HDL, Adipokines, and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women … Continue reading

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Whole Grain Cereal, Obesity, and the PI3K/Akt Pathway

Whole grain cereal contains fibers, minerals, vitamins, and phytochemicals. Whole grain cereal has been found to inhibit body weight gain and non-alcoholic fatty liver (Lee et al., 2017). Whole grain cereal could decrease the atrophy-associated factors, fat pad mass, and … Continue reading

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Psychoneuroimmunology and Anxiety: A Collection of Current Studies

Psychoneuroimmunology, Anxiety, Stress, and Inflammation Duivis HE, Vogelzangs N, Kupper N, de Jonge P, Penninx BW. Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety (NESDA). Psychoneuroendocrinology. … Continue reading

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Mindfulness, Behaviors, and Weight Loss

Can mindfulness trainings have effects on behaviors and weight control among those with overweight and obesity? A meta-analysis examined such possible effects from 12 randomized controlled trials (Ruffault et al., 2016). The studies were about the influences of mindfulness trainings … Continue reading

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Mindfulness and Obesity-Related Eating

Obesity is closely related to eating behaviors including binge eating, emotional eating and external eating (O’Reilly et al., 2014). Mindfulness-based interventions (MBIs) have been found to be helpful for easing the obesity problem by improving eating behaviors. A meta-analysis examined … Continue reading

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Mindfulness and Stress-Eating

Overweight and obesity problems have been associated with emotional eating behaviors, especially stress-related eating (Corsica et al., 2014). Although such problems are critical for weight management, it is not easy to provide effective interventions for improving eating behaviors. Potential interventions … Continue reading

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Mindful Decision-Making Training and Obesity

Excessive caloric intake such as the overeating of “junk” foods including salty snacks may contribute to the problem of obesity. Such eating decisions may be related to neurobiological preferences. The training of mindful decision-making processes may provide a helpful intervention … Continue reading

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Mindfulness, Emotional Eating, and Overweight

Mindfulness training may influence the eating habits and weight management. A recent study investigated the effects of a mindfulness and compassion-based method among 53 overweight or obese women (Palmeira et al., 2017). The study examined the possible influences of the … Continue reading

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Weight Loss Programs and Mindfulness Meditation for Obesity

Obesity is becoming a health crisis affecting more and more people. Clinical standard behavioral weight loss programs (SBWP) have been proposed to ease the problem (Spadaro et al., 2017). Such programs are often combined with trainings on mindfulness meditation (MM) … Continue reading

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Rhizoma Anemarrhenae for Infectious Diseases, Fever, and Diabetes

[Name] Rhizoma Anemarrhenae [Chinese Name] Zhi Mu [Parts Used and Preparation] Rhizome [Flavors in Chinese Medicine] Bitter, sweet; cold [Chinese Medicine Meridians/Channels] Lung, Stomach and Kidney [Actions in Chinese Medicine] The herb can clear the pathogenic Heat and Fire factors, … Continue reading

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Gypsum for Infectious Diseases, Fever, and Skin Disorders

[Name] Gypsum Fibrosum, CaSO4, Gypsum [Chinese Name] Shi Gao [Parts Used and Preparation] Gypsum (a mineral) [Flavors in Chinese Medicine] Pungent, sweet; very cold [Chinese Medicine Meridians/Channels] Lung and Stomach [Actions in Chinese Medicine] The material may clear the pathogenic … Continue reading

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Fructus Arctii for Sore Throat and Skin Rashes

[Name] Fructus Arctii, Arctium lappa [Chinese Name] Niu Bang Zi [Parts Used and Preparation] Fruits [Flavors in Chinese Medicine] Pungent, bitter; cold [Chinese Medicine Meridians/Channels] Lung and Stomach [Actions in Chinese Medicine] The herb may detoxify and relieve rashes and … Continue reading

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