Anxiety, Sleep, Fatigue, Inflammation, and Advanced Cancer

Stress, Chronic Diseases, and Psychoneuroimmunology

Stress, Depression, Inflammation, and Psychoneuroimmunology

Patients with terminal cancer are often troubled with fatigue (Rodrigues et al., 2016). Studies on the mechanisms would be helpful for improving the quality of life of the patients.

A recent study explored the associations among anxiety and depression, fatigue, sleep quality, inflammatory biomarkers, and quality of life among 51 patients with advanced solid tumors (Rodrigues et al., 2016). In the study, severe fatigue was detected in 19 patients.

Associations were identified between fatigue and the quality of sleep, as well as between the levels of fatigue and the cytokine TNF-α (Rodrigues et al., 2016). In addition, fatigue was also related to anxiety and depression, poor quality of life, and the hemoglobin levels.

In summary, the correlations between fatigue and anxiety, depression, sleep problems, poor quality of life, and inflammation indicate the requests for integrative strategies targeting both mental and physical disorders among the patient group (Rodrigues et al., 2016). Further studies in psychoneuroimmunology (PNI) may help elucidate how to apply the potential strategies for improving the quality of life for the patients.


Rodrigues AR, Trufelli DC, Fonseca F, de Paula LC, Giglio AD. Fatigue in Patients With Advanced Terminal Cancer Correlates With Inflammation, Poor Quality of Life and Sleep, and Anxiety/Depression. Am J Hosp Palliat Care. 2016 Dec;33(10):942-947.

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