Breast cancer survivors often have continuous psychological disorders such as anxiety and depression. Such mood problems may be caused by stress, and affect the quality of life (Pyter et al., 2017).
Neuroinflammation may have a critical role in the mood disorders among breast cancer survivors. Studies using mice models suggest that neuroinflammation including the genes Cd11b and Cxcl1 may be involved in the behavioral problems following mammary tumor removal (Pyter et al., 2017). The anxiety-like problems were observed together with certain central and peripheral immune biomarkers following tumor resection.
Continuous behavioral disorders such as anxiety in cancer survivors can be caused by the alterations in immune functions that continue to exist following tumor removal (Pyter et al., 2017). Such understanding may be helpful for improving cancer therapies and the effects on mental health and quality of life.
Pyter LM, Suarez-Kelly LP, Carson WE 3rd, Kaur J, Bellasario J, Bever SR. Novel rodent model of breast cancer survival with persistent anxiety-like behavior and inflammation. Behav Brain Res. 2017 May 4. pii: S0166-4328(17)30090-6. doi: 10.1016/j.bbr.2017.05.011.