Antiviral Herbal Compounds for SARS-CoV Ion Channels

Antiviral Herbal Compounds for SARS-CoV Ion Channels

(From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets)

  • The protein coded by the open-reading-frame 3a of SARS coronavirus may form a cation-selective channel (Schwarz et al., 2014).
  • The channel is important in virus release.
  • Drugs that suppress the ion channel may suppress virus release.
  • Many herbal products with anticancer effects may also have antiviral activities.
  • Such herbal products include the flavonols kaempferol, kaempferol glycosides, and acylated kaempferol glucoside derivatives.
  • These herbal products may block the 3a channel.
  • The most effective one may be the glycoside juglanin (with an arabinose residue) for blocking the 3a-mediated current.
  • Kaempferol derivatives with rhamnose residue may also have antiviral effects (Schwarz et al., 2014).
  • Coronaviral ion channels can be antiviral drug targets, e.g., the 3a channel proteins may be inhibited by kaempferol glycosides.

References:

Schwarz, S., Sauter, D., Wang, K., Zhang, R., Sun, B., Karioti, A., Bilia, A. R., Efferth, T., & Schwarz, W. (2014). Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. Planta Medica, 80(2–3), 177–182.

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