Antiviral Flavonoids from Houttuynia Cordata

Antiviral Flavonoids from Houttuynia Cordata

(From Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets)

  • The ethyl acetate (EA) fraction of Houttuynia cordata (H. cordata) Thunb. (Saururaceae) may have antiviral effects.
  • It may be used against coronaviruses and dengue virus (DENV) (Chiow et al., 2016).
  • H. cordata has flavonoids including quercetin, quercitrin and rutin.
  • The antiviral effects of H. cordata and flavonoids were tested against mouse hepatitis virus (MHV) and DENV type 2 (DENV-2).
  • The EA fraction of H. cordata suppressed viral infectivity up to 6 days.
  • The EA fraction did not cause acute toxicity in mice.
  • Some flavonoids showed weak antiviral effects, e.g., quercetin suppressed both MHV and DENV-2 (Chiow et al., 2016).  
  • Quercitrin suppressed DENV-2 but not MHV, but rutin did not inhibit either virus.
  • The combination of quercetin and quercitrin promoted anti-DENV-2 effects with decreased cytotoxicity.
  • The synergistic activities of the flavonoid combination were weaker than that of the EA fraction.
  • The flavonoids and the EA fraction of H. cordata may be antiviral against coronaviruses and dengue infections (Chiow et al., 2016).


Chiow, K. H., Phoon, M. C., Putti, T., Tan, B. K. H., & Chow, V. T. (2016). Evaluation of antiviral activities of Houttuynia cordata Thunb. Extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian Pacific Journal of Tropical Medicine, 9(1), 1–7.

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