Monthly Archives: October 2013

The dynamic brain networks, MRI, and neuroimaging biomarkers

Processes in the cerebral cortex have the nonlinear and dynamic features. Accurate temporal coordination is necessary for the establishment of functional networks and assemblies. The brain is a complex and self-organized system with serial operations involved in highly interconnected networks. … Continue reading

Posted in Brain, Connectome | Tagged , , , , , , , , , , | Leave a comment

The integration of various “omics” technologies in systems biology for better diagnosis and treatment

With the advancements in the “omics” technologies and the information technology, systems biology has become an important approach for biomarker discovery. These technologies allow faster and cheaper analyses of gene expression, protein interactions, signaling pathways, and metabolic mechanisms. In this … Continue reading

Posted in Systems Biology, Systems Medicine | Tagged , , , , , , , , , , , , , , | Leave a comment

Systems biology approaches for the pharmacokinetic/pharmacodynamic (PK/PD) modeling in drug discovery and development

Systems biology-enabled computational modeling can be useful in almost every step of drug discovery and development, including drug target identification and clinical outcome analysis. Various modeling strategies can be used at different stages. For example, during the basic scientific research … Continue reading

Posted in Systems Biology, Systems Medicine | Tagged , , , , , , , , , | Leave a comment

Systems biology strategies are useful for biomarker identification in traumatic brain injury (TBI)

The identification of biomarkers may have a significant influence on patient care. Biomarkers may be used for better diagnosis, disease profiling, research design, and drug target discovery. For instance, biomarkers have been considered to be critical in the management of … Continue reading

Posted in Systems Biology, Systems Medicine | Tagged , , , , , , , , , | Leave a comment

Systems biology and “omics” technologies for better drug discovery and outcome studies in cancer treatment

The multiple platforms using the “omics” technologies and the integration of systems biology approaches including both experimental and computational methods would support both drug target discovery and clinical outcome studies, especially in cancer treatment. For instance, immunotherapies have become an … Continue reading

Posted in Immune, Systems Biology, Systems Medicine | Tagged , , , , , , , , , , , , , , , | Leave a comment

Molecular diagnostics technologies and systems medicine for individualized treatment

The advancement of genomic and other “omics” technologies has made significant contribution to the development of molecular medicine, including the understanding of cell structure and function, as well as epigenetic variability and functional changes. Such understanding would be useful for … Continue reading

Posted in Systems Medicine | Tagged , , , , , , , , , , , , , , , , , , , | Leave a comment

Systems medicine, P4 medicine, and an integrative “Human Model”

Conventional practice in Western medicine focuses on doctors’ “reactive” interventions in response to the occurrence of diseases. With the advancement of genomics, proteomics, and various high efficient “omics” technologies, the multidimensional networks of the human body can be investigated for … Continue reading

Posted in Systems Biology, Systems Medicine | Tagged , , , , , , , , , , , , , , , , | Leave a comment