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ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) [ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-GP, PGY1] This gene belongs to the superfamily of ATP-binding cassette (ABC) transporters, and the MDR/TAP subfamily. It is an ATP-dependent drug efflux pump for xenobiotic compounds. It is associated with decreased drug accumulation in multidrug-resistant cells and the development of resistance to [...] Glycerol efflux from adipocytes to the liver is crucial for lipid and glucose homeostasis. Aquaporin 7 (AQP7) is a glycerol channel serving as a gateway of glycerol release and a regulator of adipocyte metabolism. A study done by Catalan et al. measured the gene expression of AQP7 in visceral adipose tissue (VAT) and AQP9 in liver [...] ABCA1 (ATP-binding cassette sub-family A (ABC1) member 1) is one of the most important cellular cholesterol transporters in charge of removing cholesterol from the body through cholesterol efflux. Mutations of this gene have been associated with high-density-lipoprotein (HDL) deficiency, Tangier disease and familial hypoalphalipoproteinemia. In Chinese overweight and obese patients, the expression of ABCA1 in monocytes [...]
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