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Diseases: Obesity: Aquaporin 7 (AQP7) May Be Altered

Glycerol efflux from adipocytes to the liver is crucial for lipid and glucose homeostasis. Aquaporin 7 (AQP7) is a glycerol channel serving as a gateway of glycerol release and a regulator of adipocyte metabolism.

A study done by Catalan et al. measured the gene expression of AQP7 in visceral adipose tissue (VAT) and AQP9 in liver [...]

December 11th, 2009 | Tags: , , , , , , , , , | Category: Obesity | Comments are closed

Diseases: Obesity: ABCA1

ABCA1 (ATP-binding cassette sub-family A (ABC1) member 1) is one of the most important cellular cholesterol transporters in charge of removing cholesterol from the body through cholesterol efflux. Mutations of this gene have been associated with high-density-lipoprotein (HDL) deficiency, Tangier disease and familial hypoalphalipoproteinemia.

In Chinese overweight and obese patients, the expression of ABCA1 in monocytes [...]

December 10th, 2009 | Tags: , , , , , , , , , , , , | Category: Obesity | Comments are closed

ABCA1 - Polymorphisms/Variants/SNPs/Pharmacogenomics

ABCA1

Polymorphisms/Variants/SNPs/Pharmacogenomics

dbSNP

SNP VarView

GeneView in dbSNP

Prediction:

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene. Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. PLoS Genet. 2005 Dec;1(6):e83. Epub 2005 Dec 30. PMID: 16429166

Alzheimer’s Disease:

A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer’s disease [...]

November 3rd, 2009 | Tags: , , , , , , , , , , , , , , , | Category: Diseases, Genetic Variants, Pharmacogenomics, Structure-Function | Leave a comment

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