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Diseases: Obesity: ABCA1

ABCA1 (ATP-binding cassette sub-family A (ABC1) member 1) is one of the most important cellular cholesterol transporters in charge of removing cholesterol from the body through cholesterol efflux. Mutations of this gene have been associated with high-density-lipoprotein (HDL) deficiency, Tangier disease and familial hypoalphalipoproteinemia.

In Chinese overweight and obese patients, the expression of ABCA1 in monocytes [...]

December 10th, 2009 | Tags: , , , , , , , , , , , , | Category: Obesity | Comments are closed

ABCA1 Transporter: Associated Diseases: Coronary Disease

ABCA1 Transporter: Disease Association:

Coronary Disease:

- The R219K polymorphism of ABCA1 is related with altered lipoprotein levels, and may affect the high-density lipoprotein-cholesterol (HDL-C) response to pravastatin in Chinese patients with coronary heart disease (CHD).

(Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Li [...]

November 5th, 2009 | Tags: , , , , , , , , , , | Category: Coronary Disease | Leave a comment

ABCA1 Transporter - Pathways and Cellular Interactions

ABCA1 Transporter – Pathways and Cellular Interactions

ABCA1 is involved in cellular lipid removal pathways.

Alzheimer’s disease:

Interaction between HMGCR and ABCA1 cholesterol-related genes modulates Alzheimer’s disease risk. Rodríguez-Rodríguez E, Mateo I, Infante J, Llorca J, García-Gorostiaga I, Vázquez-Higuera JL, Sánchez-Juan P, Berciano J, Combarros O. Brain Res. 2009 Jul 14;1280:166-71. Epub 2009 May 14. PMID: 19446537

Apolipoprotein:

The [...]

November 3rd, 2009 | Tags: , , , , , , , , , , , , | Category: Pathways | Leave a comment

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