Membrane Transporter Database for Personalized Medicine » coronary artery disease http://pharmtao.com/blog5 Databases and Encyclopedia of Transporters, Translational Medicine, Drug Discovery and Development Sat, 03 Apr 2010 00:42:11 +0000 http://wordpress.org/?v=2.9.2 en hourly 1 ABCA1 Transporter: Disease Association : Coronary Disease http://pharmtao.com/blog5/2009/11/05/abca1-transporter-associated-diseases-coronary-disease/ http://pharmtao.com/blog5/2009/11/05/abca1-transporter-associated-diseases-coronary-disease/#comments Fri, 06 Nov 2009 05:35:53 +0000 PharmTao.com http://pharmtao.com/blog5/?p=36 ABCA1 Transporter: Disease Association:

Coronary Disease:

- The R219K polymorphism of ABCA1 is related with altered lipoprotein levels, and may affect the high-density lipoprotein-cholesterol (HDL-C) response to pravastatin in Chinese patients with coronary heart disease (CHD).

(Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Li [...]]]> http://pharmtao.com/blog5/2009/11/05/abca1-transporter-associated-diseases-coronary-disease/feed/ 0 ABCA1 Transporter: Polymorphisms/Variants/SNPs/Pharmacogenomic http://pharmtao.com/blog5/2009/11/03/abca1-polymorphismsvariantssnpspharmacogenomics/ http://pharmtao.com/blog5/2009/11/03/abca1-polymorphismsvariantssnpspharmacogenomics/#comments Wed, 04 Nov 2009 00:34:32 +0000 PharmTao.com http://pharmtao.com/blog5/?p=16 ABCA1

Polymorphisms/Variants/SNPs/Pharmacogenomics

dbSNP

SNP VarView

GeneView in dbSNP

Prediction:

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene. Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. PLoS Genet. 2005 Dec;1(6):e83. Epub 2005 Dec 30. PMID: 16429166

Alzheimer’s Disease:

A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer’s disease [...]]]> http://pharmtao.com/blog5/2009/11/03/abca1-polymorphismsvariantssnpspharmacogenomics/feed/ 0