Membrane Transporter Pharmacogenomics and Personalized Medicine

Membrane Transporter Pharmacogenomics and Personalized Medicine:

Associations among diseases, health conditions and genetic variations, polymorphisms in transporters:

Obesity (Transporter Proteins Involved in Obesity):

ABCA1 (ATP-binding cassette sub-family A (ABC1) member 1)

ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1)

AQP7 (Aquaporin 7 )

AQP9 (aquaporin 9)

Anxiety:

SLC18A1 (solute carrier family 18 (vesicular monoamine), member 1)

SLC6A1 (solute carrier family 6 (neurotransmitter transporter, GABA), member 1)

SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Depression:

ABCA13 (ATP-binding cassette, sub-family A (ABC1), member 13)

SLC18A1 (solute carrier family 18 (vesicular monoamine), member 1)

SLC6A2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)

SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

SLCO1C1 (solute carrier organic anion transporter family, member 1C1)

Attention-Deficit Hyperactivity Disorder (ADHD):

ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1)

SLC6A2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)

SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Schizophrenia:

ABCA13 (ATP-binding cassette, sub-family A (ABC1), member 13)

ATP2B4 (ATPase, Ca++ transporting, plasma membrane 4)

ATP5A1 (ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle)

SLC17A6 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6)

ATP5H (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d)

SLC17A7 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7)

SLC18A1 (solute carrier family 18 (vesicular monoamine), member 1)

SLC18A2 (solute carrier family 18 (vesicular monoamine), member 2)

SLC1A6 (solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6)

SLC25A14 (solute carrier family 25 (mitochondrial carrier, brain), member 14)

SLC25A27 (solute carrier family 25, member 27)

SLC25A3 (solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3)

SLC32A1 (solute carrier family 32 (GABA vesicular transporter), member 1)

SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

SLC6A5 (solute carrier family 6 (neurotransmitter transporter, glycine), member 5)

UCP2 (uncoupling protein 2 (mitochondrial, proton carrier))

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